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. 1986 Aug 1;237(3):931–934. doi: 10.1042/bj2370931

Accumulation of N1-acetylspermidine in heart and spleen of isoprenaline-treated rats.

C Stefanelli, D Carati, C Rossoni, F Flamigni, C M Caldarera
PMCID: PMC1147079  PMID: 3099762

Abstract

N1-Acetylspermidine is not detectable in rat heart, but its content greatly increases after a single injection of isoprenaline (10 mg/kg), reaching a concentration of about 10 nmol/g of tissue 4 h after the treatment. Part of the accumulated N1-acetylspermidine was split to putrescine. Isoprenaline also caused an increase of N1-acetylspermidine in the spleen, where its concentration increased 3.5-fold 6 h after the catecholamine. The accumulation of N1-acetylspermidine was dependent on the dose of isoprenaline in both the heart and the spleen, and was strongly inhibited by beta-antagonists and inhibitors of protein synthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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