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. 2024 Oct 13;16(10):e71378. doi: 10.7759/cureus.71378

Table 1. An overview of the included studies.

LAI: long-acting injectible

Serial No.. Study  Title and year published Journal Sample size LAIs used Outcomes
1. Sung Wan et al.  [3] Use of long-acting injectable risperidone before and throughout pregnancy in schizophrenia (2007) Progress in Neuro-Psychopharmacology and Biological Psychiatry 1 Risperidone LAI No adverse outcomes reported
2. Orsolini et al. [4]  Severe and persistent mental illness (SPMI) in pregnancy and breastfeeding: focus on second-generation long-acting injectable antipsychotics (2021) Expert Opinion on Drug Safety 11 Five patients received  aripiprazole; one patient received  olanzapine; three patients received risperidone; two patients received paliperidone Three preterm vaginal deliveries
3. Fernandez- Abascal et al. [5] Long-acting injectable aripiprazole in pregnant women with schizophrenia: a case-series report (2021) Therapeutic Advances in Psychopharmacology 6 Aripiprazole; one woman interrupted LAI treatment at the end of the first trimester No adverse outcomes reported
4. Nguyen et al. [6] Long-acting injectable antipsychotic treatment during pregnancy: outcomes for women at a tertiary maternity hospital (2022) Psychiatry Research 36     One patient received haloperidol; two patients received fluphenazine;  nine patients received flupenthixol; 12 patients received zuclopenthixol; eight patients received aripiprazole; two patients received paliperidone; four patients received risperidone Six preterm vaginal deliveries
5. Eleftheriou et al. [1]  Long-acting  injectable antipsychotic treatment during pregnancy: a case series (2023) International Journal of Environmental Research and Public Health 15 Five patients received paliperidone;  10 patients received aripiprazole two miscarriages; one still-birth; one preterm vaginal delivery
6. Ballester-Garcia et al. [7]  Use of long-acting injectable aripiprazole before and through pregnancy in bipolar disorder: a case report  (2023) BMC Pharmacology and Toxicology 1 Aripiprazole  No adverse outcomes reported