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. 1986 Sep 15;238(3):927–929. doi: 10.1042/bj2380927

Induction of tyrosine aminotransferase in utero by anti-insulin agents.

M H Cake
PMCID: PMC1147224  PMID: 2879536

Abstract

The hepatic enzyme tyrosine aminotransferase, normally expressed in very low amounts until shortly after birth, is prematurely induced in foetal rats made diabetic by the administration of streptozotocin in utero. Similarly, the enzyme is precociously induced in foetuses if the circulating insulin concentration is artificially decreased by the administration of anti-insulin serum. These observations support the proposal that the natural decrease in plasma insulin, known to occur at birth, is a major contributor to the postnatal induction of tyrosine aminotransferase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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