Abstract
A variety of mitochondria have been observed to oxidize 13CO to 13CO2 in the presence of dioxygen, and on the basis of earlier studies [Young & Caughey (1986) Biochemistry 25, 152-161; Young (1981) Ph.D. Dissertation, Colorado State University] this activity is attributed to cytochrome c oxidase. Implications of these findings in respect of some aspects of the pathological biochemistry of CO poisoning are discussed.
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- BRECKENRIDGE B. Carbon monoxide oxidation by cytochrome oxidase in muscle. Am J Physiol. 1953 Apr;173(1):61–69. doi: 10.1152/ajplegacy.1953.173.1.61. [DOI] [PubMed] [Google Scholar]
- Bernard P. A., Cockrell R. S. The respiration of brain mitochondria and its regulation by monovalent cation transport. Biochim Biophys Acta. 1979 Nov 8;548(2):173–186. doi: 10.1016/0005-2728(79)90127-0. [DOI] [PubMed] [Google Scholar]
- Chance B., Erecinska M., Wagner M. Mitochondrial responses to carbon monoxide toxicity. Ann N Y Acad Sci. 1970 Oct 5;174(1):193–204. doi: 10.1111/j.1749-6632.1970.tb49786.x. [DOI] [PubMed] [Google Scholar]
- Luomanmäki K., Coburn R. F. Effects of metabolism and distribution of carbon monoxide on blood and body stores. Am J Physiol. 1969 Aug;217(2):354–363. doi: 10.1152/ajplegacy.1969.217.2.354. [DOI] [PubMed] [Google Scholar]
- Rasmussen H., Ogata E. Parathyroid hormone and the reactions of mitochondria to cations. Biochemistry. 1966 Feb;5(2):733–745. doi: 10.1021/bi00866a047. [DOI] [PubMed] [Google Scholar]
- Slack E. N., Bursell E. The isolation of mitochondria from dipteran flight muscle. Biochim Biophys Acta. 1976 Dec 6;449(3):491–499. doi: 10.1016/0005-2728(76)90158-4. [DOI] [PubMed] [Google Scholar]
- Yoshikawa S., Choc M. G., O'Toole M. C., Caughey W. S. An infrared study of CO binding to heart cytochrome c oxidase and hemoglobin A. Implications re O2 reactions. J Biol Chem. 1977 Aug 10;252(15):5498–5508. [PubMed] [Google Scholar]
- Young L. J., Caughey W. S. Oxygenation of carbon monoxide by bovine heart cytochrome c oxidase. Biochemistry. 1986 Jan 14;25(1):152–161. doi: 10.1021/bi00349a022. [DOI] [PubMed] [Google Scholar]