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. 1986 Nov 1;239(3):575–580. doi: 10.1042/bj2390575

6-beta-Iodopenicillanate as a probe for the classification of beta-lactamases.

F De Meester, J M Frère, S G Waley, S J Cartwright, R Virden, F Lindberg
PMCID: PMC1147325  PMID: 3030266

Abstract

An inactivator of serine beta-lactamases, 6 beta-iodopenicillanate, can be utilized as a probe in the classification of beta-lactamases. It is a substrate for class-B Zn2+-containing beta-lactamase II. Although it inactivates enzymes from both classes A and C, it is much more efficient for the former group, with which it sometimes interacts following a branched pathway. On the basis of these observations, predictions are made concerning the class to which several enzymes belong.

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Selected References

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