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. 1986 Nov 15;240(1):297–300. doi: 10.1042/bj2400297

Haemosiderin-like properties of free-radical-modified ferritin.

M J O'Connell, H Baum, T J Peters
PMCID: PMC1147411  PMID: 3827850

Abstract

Conjugated-Schiff's-base-type fluorescence was measured in iron-depleted samples and chloroform extracts of human spleen haemosiderin. Incubation of ferritin with liposomes and ascorbate led to the formation of compounds with similar fluorescence properties. Analysis of protein subunits by SDS/polyacrylamide-gel electrophoresis confirmed that ferritin was damaged in incubations with ascorbate. Since previous studies have shown that intact ferritin is resistant to proteolytic degradation, it is suggested that haemosiderin may be a product of oxidative reactions involving ferritin and lipid.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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