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. 1987 Feb 15;242(1):297–300. doi: 10.1042/bj2420297

Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats.

J Kapitulnik, J P Hardwick, J D Ostrow, C C Webster, S S Park, H V Gelboin
PMCID: PMC1147698  PMID: 3593244

Abstract

Congenitally jaundiced (jj) Gunn rats had a greater hepatic microsomal content of a cytochrome P-450 isoenzyme, P-450c, than did the non-jaundiced (Jj) rats. No differences in content of P-450b, P-450d and pregnenolone-16 alpha-carbonitrile-induced (PCN) P-450 were found between jj and Jj rats. This is the first demonstration of a constitutive increase in a specific cytochrome P-450 isoenzyme in association with a genetic defect.

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Selected References

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