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. 1987 Mar 15;242(3):931–934. doi: 10.1042/bj2420931

Role of growth hormone in the adaptations of lipolysis in rat adipocytes during recovery from lactation.

R G Vernon, E Finley, D J Flint
PMCID: PMC1147799  PMID: 3593287

Abstract

Removal of the litter from lactating rats results in a fall in the rate of noradrenaline-stimulated lipolysis of adipocytes. This adaptation can be prevented by administration of growth hormone (somatotropin) to such rats and mimicked by injecting lactating rats with an antiserum to growth hormone, whereas lowering serum prolactin by injecting bromocriptine had no effect. The anti-lipolytic effect of adenosine is increased during lactation and is still increased by 2 days after litter removal. Injection of growth hormone into lactating rats decreased slightly the response to adenosine, whereas injection of growth hormone into rats after removal of their litters resulted in a much greater decrease in the response to adenosine, to that found in virgin and pregnant rats.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Agius L., Robinson A. M., Girard J. R., Williamson D. H. Alterations in the rate of lipogenesis in vivo in maternal liver and adipose tissue on premature weaning of lactating rats: a possible regulatory role of prolactin. Biochem J. 1979 Jun 15;180(3):689–692. doi: 10.1042/bj1800689. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Aitchison R. E., Clegg R. A., Vernon R. G. Lipolysis in rat adipocytes during pregnancy and lactation. The response to noradrenaline. Biochem J. 1982 Jan 15;202(1):243–247. doi: 10.1042/bj2020243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Amenomori Y., Chen C. L., Meites J. Serum prolactin levels in rats during different reproductive states. Endocrinology. 1970 Mar;86(3):506–510. doi: 10.1210/endo-86-3-506. [DOI] [PubMed] [Google Scholar]
  4. Burnol A. F., Leturque A., Ferré P., Girard J. Glucose metabolism during lactation in the rat: quantitative and regulatory aspects. Am J Physiol. 1983 Oct;245(4):E351–E358. doi: 10.1152/ajpendo.1983.245.4.E351. [DOI] [PubMed] [Google Scholar]
  5. Flint D. J., Clegg R. A., Vernon R. G. Prolactin and the regulation of adipose-tissue metabolism during lactation in rats. Mol Cell Endocrinol. 1981 May;22(2):265–275. doi: 10.1016/0303-7207(81)90096-4. [DOI] [PubMed] [Google Scholar]
  6. Hamosh M., Clary T. R., Chernick S. S., Scow R. O. Lipoprotein lipase activity of adipose and mammary tissue and plasma triglyceride in pregnant and lactating rats. Biochim Biophys Acta. 1970 Sep 8;210(3):473–482. doi: 10.1016/0005-2760(70)90044-5. [DOI] [PubMed] [Google Scholar]
  7. Johnson C. L. Some aspects of changing body composition of mice during successive pregnancies and lactations. J Endocrinol. 1973 Jan;56(1):37–46. doi: 10.1677/joe.0.0560037. [DOI] [PubMed] [Google Scholar]
  8. Liberti J. P., Joshi G. S. Synthesis and secretion of phosphorylated growth hormone by rat pituitary glands in vitro. Biochem Biophys Res Commun. 1986 Jun 13;137(2):806–812. doi: 10.1016/0006-291x(86)91151-4. [DOI] [PubMed] [Google Scholar]
  9. Madon R. J., Ensor D. M., Knight C. H., Flint D. J. Effects of an antiserum to rat growth hormone on lactation in the rat. J Endocrinol. 1986 Oct;111(1):117–123. doi: 10.1677/joe.0.1110117. [DOI] [PubMed] [Google Scholar]
  10. Scow R. O., Chernick S. S., Fleck T. R. Lipoprotein lipase and uptake of triacylglycerol, cholesterol and phosphatidylcholine from chylomicrons by mammary and adipose tissue of lactating rats in vivo. Biochim Biophys Acta. 1977 May 25;487(2):297–306. doi: 10.1016/0005-2760(77)90006-6. [DOI] [PubMed] [Google Scholar]
  11. Silverlight J. J., Prysor-Jones R. A., Jenkins J. S. Growth hormone in normal female rat plasma appears on gel filtration as a large molecular weight form. Life Sci. 1985 May 20;36(20):1927–1932. doi: 10.1016/0024-3205(85)90441-2. [DOI] [PubMed] [Google Scholar]
  12. Vernon R. G., Clegg R. A., Flint D. J. Metabolism of sheep adipose tissue during pregnancy and lactation. Adaptation and regulation. Biochem J. 1981 Nov 15;200(2):307–314. doi: 10.1042/bj2000307. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Vernon R. G., Finley E. Lipolysis in rat adipocytes during recovery from lactation. Response to noradrenaline and adenosine. Biochem J. 1986 Feb 15;234(1):229–231. doi: 10.1042/bj2340229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Vernon R. G., Finley E. Regulation of lipolysis during pregnancy and lactation in sheep. Response to noradrenaline and adenosine. Biochem J. 1985 Sep 15;230(3):651–656. doi: 10.1042/bj2300651. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Vernon R. G., Finley E., Taylor E. Adenosine and the control of lipolysis in rat adipocytes during pregnancy and lactation. Biochem J. 1983 Oct 15;216(1):121–128. doi: 10.1042/bj2160121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Vernon R. G., Flint D. J. Control of fatty acid synthesis in lactation. Proc Nutr Soc. 1983 Jun;42(2):315–331. doi: 10.1079/pns19830035. [DOI] [PubMed] [Google Scholar]

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