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. 1987 May 1;243(3):859–861. doi: 10.1042/bj2430859

Development of multiple activities of UDP-glucuronyltransferase in human liver.

J E Leakey 1, R Hume 1, B Burchell 1
PMCID: PMC1147936  PMID: 3117034

Abstract

UDP-glucuronyltransferase activities towards eight substrates were assayed in samples of foetal, term and adult human liver. Activities towards bilirubin, androsterone, testosterone, 1-naphthol, 4-nitrophenol and 2-aminophenol were present in foetal and term liver samples at less than 14% of adult values, whereas activity towards 5-hydroxytryptamine was present in foetal and term liver at 109 and 121% of adult values respectively. Thus a 'foetal' form of UDP-glucuronyltransferase may exist in human liver that is more restricted in substrate specificity than are those of the rat or rhesus monkey.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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