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. 1987 May 15;244(1):231–234. doi: 10.1042/bj2440231

Chemical synthesis and growth-promoting activity of all-trans-retinyl beta-D-glucuronide.

A B Barua 1, J A Olson 1
PMCID: PMC1147976  PMID: 3663114

Abstract

All-trans-retinol reacts with methyl (2,3,4-tri-O-acetyl-1-bromo-1-deoxy-beta-D-glucopyran)uronate in the presence of Ag2CO3 to give the triacetate methyl ester of retinyl beta-glucuronide. Hydrolysis of this ester with sodium methylate in methanol gives retinyl beta-D-glucuronide in about 15% yield. The water-soluble retinyl beta-D-glucuronide was characterized by u.v.-visible, n.m.r. and mass spectra, by elemental analysis and by its susceptibility to hydrolysis by bacterial beta-glucuronidase. Retinyl beta-glucuronide, when administered intraperitoneally in saline (0.9% NaCl), supports well the growth of vitamin A-deficient rats.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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