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. 1987 Jun 1;244(2):493–496. doi: 10.1042/bj2440493

Binding of inositol phosphates and induction of Ca2+ release from pituitary microsomal fractions.

A Spät 1, G L Lukács 1, I Eberhardt 1, L Kiesel 1, B Runnebaum 1
PMCID: PMC1148018  PMID: 3663137

Abstract

Bovine anterior-pituitary microsomal fractions exhibit high-affinity, saturable and reversible binding of inositol 1,4,5-[32P]trisphosphate; 50% of the labelled ligand is displaced by 3.5 nM-inositol 1,4,5-trisphosphate. 0.5 microM-inositol 1,4-bisphosphate and 10 microM-ATP. Inositol 1,4,5-trisphosphate induces the release of Ca2+ from the microsomal vesicles (half-maximal effect at 290 nM), and its action is potentiated by inositol tetrakisphosphate (half-maximal effect at 4 microM).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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