表 1.
108例性早熟女童的临床特征
Clinical characteristics of 108 girls with precocious puberty
| Items | CPP group (n=45) | Non-CPP group (n=63) | F/χ2χvalue | P value |
| Data are expressed as x±s or median (P25, P75). CPP, central precocious puberty; BMI, body mass index; LH, luteinizing hormone; GnRH, gonadotropin-releasing hormone; FSH, follicular stimulating hormone. | ||||
| Age/years | 7.8±0.8 | 7.1±0.9 | 2.765 | 0.099 |
| Height/cm | 134.4±6.8 | 127.6±6.9 | 0.179 | 0.673 |
| Weight/kg | 31.1±5.9 | 27.2±5.2 | 0.645 | 0.424 |
| BMI/(kg/m2) | 17.1±2.2 | 16.6±2.2 | 0.295 | 0.588 |
| Bone age/years | ||||
| R bone age | 9.4±0.9 | 8.2±1.0 | 1.550 | 0.217 |
| C bone age | 9.9±1.5 | 8.4±1.3 | 0.059 | 0.809 |
| T bone age | 9.8±0.9 | 8.6±1.2 | 1.715 | 0.194 |
| Advanced R bone age | 2.0 (1.5, 2.6) | 1.7 (0.8, 2.0) | 2.952 | 0.003 |
| Advanced C bone age | 2.2 (1.5, 2.7) | 1.4 (0.5, 1.8) | 3.428 | 0.001 |
| Advanced T bone age | 1.5 (1.2, 1.9) | 1.3 (0.5, 1.6) | 2.783 | 0.005 |
| Urine LH/(IU/L) | 2.94 (1.04, 8.09) | 0.65 (0.38, 1.48) | 5.060 | ＜0.001 |
| GnRH stimulation test/(IU/L) | ||||
| Basal serum LH/(IU/L) | 0.67 (0.26, 3.13) | 0.21 (0.15, 0.40) | 4.368 | ＜0.001 |
| Peak serum LH/(IU/L) | 16.10 (8.32, 23.15) | 3.50(2.21, 4.66) | 8.179 | ＜0.001 |
| Basal serum FSH/(IU/L) | 3.22 (1.69, 5.73) | 1.89 (1.42, 2.91) | 3.218 | 0.001 |
| Peak serum FSH/(IU/L) | 14.20 (10.35, 20.00) | 14.95 (11.48, 19.18) | -0.230 | 0.818 |
| Basal serum estrogen/(pmol/L) | 115.0 (73.4, 162.5) | 98.8 (73.4, 124.8) | 0.807 | 0.420 |
| Peak serum estrogen/(pmol/L) | 449.0 (297.5, 743.5) | 244.0 (188.0, 381.5) | 4.350 | ＜0.001 |
| Uterine volume/mL | 2.78 (2.00, 3.63) | 1.30 (0.98, 2.01) | 4.991 | ＜0.001 |
| Ovarian volume/mL | 3.16 (2.33, 5.13) | 2.38 (1.80, 3.51) | 2.822 | 0.005 |