Skip to main content
Biochemical Journal logoLink to Biochemical Journal
. 1987 Jul 1;245(1):297–300. doi: 10.1042/bj2450297

Hepatic uptake of amino acids at mid-lactation in the rat.

J Casado 1, M Pastor-Anglada 1, X Remesar 1
PMCID: PMC1148116  PMID: 3663155

Abstract

Hepatic availability and uptake of amino acids were measured in fed virgin and 15-day-lactating rats. Lactation did not induce any change in total amino acid availability (expressed per 100 g body wt.). Virgin rats showed a nil hepatic balance, and lactation induced a high net uptake. The high drainage of amino acids by mammary gland does not affect hepatic availability.

Full text

PDF
297

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Burnol A. F., Leturque A., Ferré P., Girard J. Glucose metabolism during lactation in the rat: quantitative and regulatory aspects. Am J Physiol. 1983 Oct;245(4):E351–E358. doi: 10.1152/ajpendo.1983.245.4.E351. [DOI] [PubMed] [Google Scholar]
  2. FELL B. F., SMITH K. A., CAMPBELL R. M. Hypertrophic and hyperplastic changes in the alimentary canal of the lactating rat. J Pathol Bacteriol. 1963 Jan;85:179–188. doi: 10.1002/path.1700850117. [DOI] [PubMed] [Google Scholar]
  3. Fafournoux P., Rémésy C., Demigné C. Control of alanine metabolism in rat liver by transport processes or cellular metabolism. Biochem J. 1983 Mar 15;210(3):645–652. doi: 10.1042/bj2100645. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Freinkel N., Metzger B. E., Nitzan M., Hare J. W., Shambaugh G. E., 3rd, Marshall R. T., Surmaczynska B. Z., Nagel T. C. "Accelerated starvation" and mechanisms for the conservation of maternal nitrogen during pregnancy. Isr J Med Sci. 1972 Mar;8(3):426–439. [PubMed] [Google Scholar]
  5. Hanwell A., Linzell J. L. The time course of cardiovascular changes in lactation in the rat. J Physiol. 1973 Aug;233(1):93–109. doi: 10.1113/jphysiol.1973.sp010299. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. James D. E., Burleigh K. M., Storlien L. H., Bennett S. P., Kraegen E. W. Heterogeneity of insulin action in muscle: influence of blood flow. Am J Physiol. 1986 Oct;251(4 Pt 1):E422–E430. doi: 10.1152/ajpendo.1986.251.4.E422. [DOI] [PubMed] [Google Scholar]
  7. Jones R. G., Williamson D. H. Alterations in mammary-gland blood flow and glucose metabolism in the lactating rat induced by short-term starvation and refeeding. Biosci Rep. 1984 May;4(5):421–426. doi: 10.1007/BF01122507. [DOI] [PubMed] [Google Scholar]
  8. Katz M. L., Bergman E. N. Simultaneous measurements of hepatic and portal venous blood flow in the sheep and dog. Am J Physiol. 1969 Apr;216(4):946–952. doi: 10.1152/ajplegacy.1969.216.4.946. [DOI] [PubMed] [Google Scholar]
  9. Mercer S. W., Williamson D. H. Time course of changes in plasma glucose and insulin concentrations and mammary-gland lipogenesis during re-feeding of starved conscious lactating rats. Biochem J. 1986 Oct 15;239(2):489–492. doi: 10.1042/bj2390489. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Moule S. K., Bradford N. M., McGivan J. D. Short-term stimulation of Na+-dependent amino acid transport by dibutyryl cyclic AMP in hepatocytes. Characteristics and partial mechanism. Biochem J. 1987 Feb 1;241(3):737–743. doi: 10.1042/bj2410737. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Pastor-Anglada M., Remesar X., Bourdel G. Alanine uptake by liver at midpregnancy in rats. Am J Physiol. 1987 Mar;252(3 Pt 1):E408–E413. doi: 10.1152/ajpendo.1987.252.3.E408. [DOI] [PubMed] [Google Scholar]
  12. Pastor-Anglada M., Remesar X. No significant net uptake of branched chain amino acids by the liver of fed-mid pregnant rats. Biochem Int. 1986 Jun;12(6):957–962. [PubMed] [Google Scholar]
  13. Remesy C., Fafournoux P., Demigne C. Control of hepatic utilization of serine, glycine and threonine in fed and starved rats. J Nutr. 1983 Jan;113(1):28–39. doi: 10.1093/jn/113.1.28. [DOI] [PubMed] [Google Scholar]
  14. Rémésey C., Demigné C., Aufrère J. Inter-organ relationships between glucose, lactate and amino acids in rats fed on high-carbohydrate or high-protein diets. Biochem J. 1978 Feb 15;170(2):321–329. doi: 10.1042/bj1700321. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Rémésy C., Demigné C. Changes in availability of glucogenic and ketogenic substrates and liver metabolism in fed or starved rats. Ann Nutr Metab. 1983;27(1):57–70. doi: 10.1159/000176624. [DOI] [PubMed] [Google Scholar]
  16. Viña J. R., Puertes I. R., Viña J. Effect of premature weaning on amino acid uptake by the mammary gland of lactating rats. Biochem J. 1981 Dec 15;200(3):705–708. doi: 10.1042/bj2000705. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Viña J. R., Williamson D. H. Effects of lactation on L-leucine metabolism in the rat. Studies in vivo and in vitro. Biochem J. 1981 Mar 15;194(3):941–947. doi: 10.1042/bj1940941. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Viña J. R., Williamson D. H. Utilization of L-alanine and L-glutamine by lactating mammary gland of the rat. A role for L-alanine as a lipogenic precursor. Biochem J. 1981 Jun 15;196(3):757–762. doi: 10.1042/bj1960757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Viña J., Puertes I. R., Estrela J. M., Viña J. R., Galbis J. L. Involvement of gamma-glutamyltransferase in amino-acid uptake by the lactating mammary gland of the rat. Biochem J. 1981 Jan 15;194(1):99–102. doi: 10.1042/bj1940099. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Williamson D. H. Regulation of metabolism during lactation in the rat. Reprod Nutr Dev. 1986;26(2B):597–603. doi: 10.1051/rnd:19860409. [DOI] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES