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. 1987 Jul 15;245(2):609–612. doi: 10.1042/bj2450609

The modulation of serine metabolism in hepatoma 3924A during different phases of cellular proliferation in culture.

K Snell 1, Y Natsumeda 1, G Weber 1
PMCID: PMC1148165  PMID: 3117048

Abstract

The activities of 3-phosphoglycerate dehydrogenase and serine hydroxymethyltransferase increased markedly during the transition of hepatoma cells from a resting non-proliferating culture into the proliferating growth phase. Activities declined as cells reached confluency and entered the plateau growth phase. This pattern was paralleled by changes in [14C]serine incorporation into nucleic acids. The experiments support the hypothesis that the biosynthesis of serine is metabolically coupled to its utilization for nucleotide precursor formation in cancer cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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