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. 1987 Dec 1;248(2):483–487. doi: 10.1042/bj2480483

Platelet-reactive sites in collagen. Collagens I and III possess different aggregatory sites.

L F Morton 1, C M Fitzsimmons 1, J Rauterberg 1, M J Barnes 1
PMCID: PMC1148567  PMID: 3124815

Abstract

Collagen type III possesses a highly reactive platelet-aggregatory site at a locus which in type I is essentially inactive whilst the latter collagen possesses reactive sites absent in type III. It is proposed that platelet aggregation by collagen involves the sequence GK[or R]PG(EY)GPK[or R]G(EY) or, less favourably, GPK[or R]G(EY)G(XY)GK[or R]PG(EY), one basic residue acting in combination with the second in an adjacent alpha-chain.

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Selected References

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