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. 1988 Jan 1;249(1):143–148. doi: 10.1042/bj2490143

The dephosphorylation of inositol 1,4-bisphosphate to inositol in liver and brain involves two distinct Li+-sensitive enzymes and proceeds via inositol 4-phosphate.

C I Ragan 1, K J Watling 1, N S Gee 1, S Aspley 1, R G Jackson 1, G G Reid 1, R Baker 1, D C Billington 1, R J Barnaby 1, P D Leeson 1
PMCID: PMC1148677  PMID: 2829849

Abstract

1. Hydrolysis of both enantiomers of inositol 1-phosphate and both enantiomers of inositol 4-phosphate to inositol is inhibited by LiCl in liver and brain. 2. The phosphatase activity is predominantly soluble. 3. Inositol 1,4-bisphosphate is also hydrolysed by the soluble fraction of liver and brain. 4. Bisphosphatase activity is inhibited by LiCl, but is less sensitive than monophosphatase activity. 5. The product of bisphosphatase in liver and brain is inositol 4-phosphate.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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