Table 3.
Baseline comparison of older individuals with mild cognitive impairment (MCI) by white matter hyperintensities (WMH) status.
| Variable | CHS score <5 (n= 2611) |
CHS score: 5–6 (n= 471) |
CHS score: 7–8 (n= 88) |
P-value |
|---|---|---|---|---|
| Age in years | 71.8 ±8.8 | 76.9 ±7.2 | 78.8 ±7.3 | <.001 |
| Formal education in years | 16.1 ±3.1 | 16.0 ±3.0 | 15.5 ±3.4 | .283 |
| Mini-mental state-examination score | 27.4 ±2.6 | 27.1 ±2.5 | 26.8 ±2.5 | .012 |
| Sex (male/female %) | 1355/1256 (83/81%) | 226/245 (14/16%) | 48/40 (3/3%) | .246 |
| Race (Caucasian / African American / other %) | 2240/240/131 (83/73/82%) | 374/74/23 (14/22/15%) | 68/15/5 (3/5/3%) | <.001 |
| Cerebrovascular disease(No/Yes %) | 2486/125 (84/62%) | 415/56 (14/27%) | 66/22 (2/11%) | <.001 |
| Atrial fibrillation (No/Yes %) | 2423/177 (83/73%) | 416/54 (14/22%) | 75/11 (3/5%) | <.001 |
| Diabetes mellitus (No/Yes %) | 2250/234 (83/76%) | 380/62 (14/20%) | 67/11 (3/4%) | .007 |
| Hypertension (No/Yes %) | 1362/1238 (88/77%) | 161/310 (10/19%) | 23/65 (2/4%) | <.001 |
| Dyslipidaemia (No/Yes %) | 1156/1431 (86/80%) | 155/309 (12/17%) | 26/62 (2/3%) | <.001 |
| Average number of NPS per individual | 2.10 ±2.14 | 2.07 ±2.09 | 1.61 ±1.99 | .136 |
| Average NPS severity per individual | 2.84 ±3.31 | 2.80 ±3.21 | 2.15 ±3.18 | .203 |
| Psychotic symptoms (No/Yes %) | 2337/129 (82/83%) | 421/23 (15/15%) | 78/3 (3/2%) | .830 |
| Depression (No/Yes %) | 1602/856 (82/84%) | 300/141 (15/14%) | 60/21 (3/2%) | .145 |
| Anxiety (No/Yes %) | 1654/806 (82/83%) | 294/149 (15/15%) | 62/19 (3/2%) | .190 |
| Agitation (No/Yes %) | 2041/423 (82/84%) | 369/74 (15/14%) | 73/8 (3/2%) | .225 |
| Disinhibition (No/Yes %) | 2172/291 (83/81%) | 382/61 (14/17%) | 72/9 (3/2%) | .490 |
| Irritability (No/Yes %) | 1668/797 (83/82%) | 293/150 (14/15%) | 57/24 (3/3%) | .701 |
| Elation (No/Yes %) | 2400/66 (82/84%) | 430/13 (15/16%) | 81/0 (3/0%) | .308 |
| Apathy (No/Yes %) | 1912/554 (82/84%) | 352/91 (15/14%) | 67/14 (3/2%) | .386 |
| Motor symptoms (No/Yes %) | 2273/194 (82/83%) | 408/34 (15/15%) | 76/5 (3/2%) | .852 |
| Appetite disorders (No/Yes %) | 2045/414 (82/84%) | 374/69 (15/14%) | 70/11 (3/2%) | .617 |
| Night-time behaviours (No/Yes %) | 1762/658 (82/84%) | 323/112 (15/14%) | 62/14 (3/2%) | .207 |
Bold denotes statistically significant differences between the two groups; CHS: cardiovascular health study.