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. 1988 Mar 15;250(3):917–920. doi: 10.1042/bj2500917

Proteus mirabilis urease. Partial purification and inhibition by boric acid and boronic acids.

J M Breitenbach 1, R P Hausinger 1
PMCID: PMC1148943  PMID: 3291857

Abstract

Urease was purified 800-fold and partially characterized from Proteus mirabilis, the predominant microorganism associated with urinary stones. Boric acid is a rapid reversible competitive inhibitor of urease. The pH-dependence of inhibition exhibited pKa values of 6.25 and 9.3, where the latter value is probably due to the inherent pKa of boric acid. Three boronic acids also were shown to inhibit urease competitively.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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