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. 1988 Apr 15;251(2):547–551. doi: 10.1042/bj2510547

Chronic ethanol administration depresses fatty acid synthesis in rat adipose tissue.

J S Wilson 1, M A Korsten 1, L P Donnelly 1, P W Colley 1, J B Somer 1, R C Pirola 1
PMCID: PMC1149035  PMID: 2900003

Abstract

Administration of ethanol as part of a nutritionally adequate liquid diet to female Wistar rats was found to depress markedly incorporation of labelled glucose into adipose-tissue acylglycerol fatty acids. Similar results with labelled pyruvate and acetate suggested inhibition of the fatty-acid-synthesis pathway at, or distal to, the acetyl-CoA carboxylase step. Activities of acetyl-CoA carboxylase and fatty acid synthetase were markedly lower in ethanol-fed animals. The activity of another lipogenic enzyme, phosphatidate phosphohydrolase, was not affected by chronic ethanol feeding. These findings suggest that chronic ethanol administration has marked effects on adipose-tissue lipogenesis.

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Selected References

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