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. 1988 May 15;252(1):293–296. doi: 10.1042/bj2520293

Changes in brown-adipose-tissue mitochondrial processes in streptozotocin-diabetes.

Z Jamal 1, E D Saggerson 1
PMCID: PMC1149137  PMID: 3421907

Abstract

Diabetic rats were used as a source of brown-adipose-tissue mitochondria 2 days after a single subcutaneous injection of streptozotocin (100 mg/kg). Diabetes caused an 80% decrease in carnitine-dependent oxidation of palmitoyl-CoA and a 50-60% decrease in overt carnitine palmitoyltransferase activity. An additional lesion in brown-adipose-tissue mitochondrial oxidative capacity was also indicated, since diabetes increased by 30-50% the rate of oxidation under uncoupled conditions of several respiratory substrates (i.e. malate + palmitoylcarnitine, malate + pyruvate, succinate, NNN'N'-tetramethyl-p-phenylenediamine + ascorbate). This decrease in mitochondrial function was accompanied by an approx. 30% decrease in the abundance of cytochromes (a + a3) and total cytochromes b.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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