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. 2024 Oct;28(67):1–100. doi: 10.3310/JTNT0476

Care models for coexisting serious mental health and alcohol/drug conditions: the RECO realist evidence synthesis and case study evaluation.

Elizabeth Hughes, Jane Harris, Tom Ainscough, Angela Bate, Alex Copello, Sonia Dalkin, Gail Gilchrist, Emma Griffith, Lisa Jones, Michelle Maden, Luke Mitcheson, Harry Sumnall, Charlotte Walker
PMCID: PMC11491988  PMID: 39400110

Abstract

BACKGROUND

People with severe mental illness who experience co-occurring substance use experience poor outcome including suicide, violence, relapses and use of crisis services. They struggle to access care and treatment due to a lack of an integrated and co-ordinated approach which means that some people can fall between services. Despite these concerns, there is limited evidence as to what works for this population.

OBJECTIVES

To undertake a realist evaluation of service models in order to identify and refine programme theories of what works under what contexts for this population.

DESIGN

Realist synthesis and evaluation using published literature and case study data.

SETTING

Mental health, substance use and related services that had some form of service provision in six locations in the United Kingdom (five in England and one in Northern Ireland).

PARTICIPANTS

People with lived experience of severe mental illness and co-occurring substance use, carers and staff who work in the specialist roles as well as staff in mental health and substance use services.

RESULTS

Eleven initial programme theories were generated by the evidence synthesis and in conjunction with stakeholders. These theories were refined through focus groups and interviews with 58 staff, 25 service users and 12 carers across the 6 case study areas. We identified three forms of service provision (network, consultancy and lead and link worker); however, all offered broadly similar interventions. Evidence was identified to support most of the 11 programme theories. Theories clustered around effective leadership, workforce development and collaborative integrated care pathways. Outcomes that are meaningful for service users and staff were identified, including the importance of engagement.

LIMITATIONS

The requirement for online data collection (due to the COVID-19 pandemic) worked well for staff data but worked less well for service users and carers. Consequently, this may have reduced the involvement of those without access to information technology equipment.

CONCLUSION

The realist evaluation co-occurring study provides details on how and in what circumstances integrated care can work better for people with co-occurring severe mental health and alcohol/drug conditions. This requires joined-up policy at government level and local integration of services. We have also identified the value of expert clinicians who can support the workforce in sustaining this programme of work. People with co-occurring severe mental health and alcohol/drug conditions have complex and multifaceted needs which require a comprehensive and long-term integrated approach. The shift to integrated health and social care is promising but will require local support (local expert leaders, network opportunities and clarity of roles).

FUTURE WORK

Further work should evaluate the effectiveness and cost-effectiveness of service models for this group.

STUDY REGISTRATION

This study is registered as PROSPERO CRD42020168667.

FUNDING

This award was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme (NIHR award ref: NIHR128128) and is published in full in Health Technology Assessment; Vol. 28, No. 67. See the NIHR Funding and Awards website for further award information.

Plain language summary

There are very few services in the United Kingdom that currently provide a service for people with co-occurring severe mental health and alcohol/drug conditions. We identified a set of factors that are likely to promote better outcomes for people with co-occurring severe mental health and alcohol/drug conditions including commitment from leaders across organisations to address this issue and support staff training. A local expert clinical leader was seen to be important in enabling closer working between mental health and substance use. Service users and carers recognised that when care was co-ordinated, and staff demonstrated empathy and compassion, they were more likely to engage in treatment. Further work will be needed to evaluate how helpful some of the aspects of the models of care are in helping people in their recovery goals.


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References

  1. Regier DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, Judd LL, Goodwin FK. Comorbidity of mental disorders with alcohol and other drug abuse: results from the Epidemiologic Catchment Area (ECA) study. JAMA 1990;264(19):2511–8. [PubMed]
  2. Menezes PR, Johnson S, Thornicroft G, Marshall J, Prosser D, Bebbington P, Kuipers E. Drug and alcohol problems among individuals with severe mental illness in south London. Br J Psychiatry 1996;168:612–9. doi: 10.1192/bjp.168.5.612. [DOI] [PubMed]
  3. Adams MW. Comorbidity of mental health and substance misuse problems: a review of workers’ reported attitudes and perceptions. J Psychiatr Ment Health Nurs 2008;15(2):101–8. doi: 10.1111/j.1365-2850.2007.01210.x. [DOI] [PubMed]
  4. McGovern MP, Xie H, Segal SR, Siembab L, Drake RE. Addiction treatment services and co-occurring disorders: prevalence estimates, treatment practices, and barriers. J Subst Abuse Treat 2006;31(3):267–75. doi: 10.1016/j.jsat.2006.05.003. [DOI] [PubMed]
  5. Popovic D, Benabarre A, Crespo JM, Goikolea JM, Gonzalez-Pinto A, Gutierrez-Rojas L, et al. Risk factors for suicide in schizophrenia: systematic review and clinical recommendations. Acta Psychiatr Scand 2014;130(6):418–26. doi: 10.1111/acps.12332. [DOI] [PubMed]
  6. Fazel S, Buxrud P, Ruchkin V, Grann M. Homicide in discharged patients with schizophrenia and other psychoses: a national case-control study. Schizophr Res 2010;123(2–3):263–9. doi: 10.1016/j.schres.2010.08.019. [DOI] [PubMed]
  7. Witt K, van Dorn R, Fazel S. Risk factors for violence in psychosis: systematic review and meta-regression analysis of 110 studies. PLOS ONE 2013;8(2):e55942. doi: 10.1371/journal.pone.0055942. [DOI] [PMC free article] [PubMed]
  8. Wright S, Gournay K, Glorney E, Thornicroft G. Dual diagnosis in the suburbs: prevalence, need, and in-patient service use. Soc Psychiatry Psychiatr Epidemiol 2000;35:297–304. doi: 10.1007/s001270050242. [DOI] [PubMed]
  9. McCrone P, Menezes PR, Johnson S, Scott H, Thornicroft G, Marshall J, et al. Service use and costs of people with dual diagnosis in South London. Acta Psychiatr Scand 2000;101(6):464–72. doi: 10.1034/j.1600-0447.2000.101006464.x. [DOI] [PubMed]
  10. Robson D, Keen S, Mauro P. Physical health and dual diagnosis. Adv Dual Diagn 2008;1(1):27–32. doi: 10.1108/17570972200800006. [DOI] [PMC free article] [PubMed]
  11. Fazel S, Khosla V, Doll H, Geddes J. The prevalence of mental disorders among the homeless in western countries: systematic review and meta-regression analysis. PLOS Med 2008;5(12):e225. doi: 10.1371/journal.pmed.0050225. [DOI] [PMC free article] [PubMed]
  12. Weaver T, Rutter D, Madden P, Ward J, Stimson G, Renton A. Results of a screening survey for co-morbid substance misuse amongst patients in treatment for psychotic disorders: prevalence and service needs in an inner London borough. Soc Psychiatry Psychiatr Epidemiol 2001;36(8):399–406. doi: 10.1007/s001270170030. [DOI] [PubMed]
  13. Hunt GE, Siegfried N, Morley K, Brooke-Sumner C, Cleary M. Psychosocial interventions for people with both severe mental illness and substance misuse. Cochrane Database Syst Rev 2019;12:CD001088. doi: 10.1002/14651858.CD001088.pub4. [DOI] [PMC free article] [PubMed]
  14. Horsfall J, Cleary M, Hunt GE, Walter G. Psychosocial treatments for people with co-occurring severe mental illnesses and substance use disorders (dual diagnosis): a review of empirical evidence. Harv Rev Psychiatry 2009;17(1):24–34. doi: 10.1080/10673220902724599. [DOI] [PubMed]
  15. Drake RE, Mercer-McFadden C, Mueser KT, McHugo GJ, Bond GR. Review of integrated mental health and substance abuse treatment for patients with dual disorders. Schizophr Bull 1998;24:589–608. doi: 10.1093/oxfordjournals.schbul.a033351. [DOI] [PubMed]
  16. Petrakis M, Robinson R, Myers K, Kroes S, O’Connor S. Dual diagnosis competencies: a systematic review of staff training literature. Addict Behav Rep 2018;7:53–7. doi: 10.1016/j.abrep.2018.01.003. [DOI] [PMC free article] [PubMed]
  17. Department of Health. Mental Health Policy Implementation Guide: Dual Diagnosis Good Practice Guide. London: Department of Health; 2002.
  18. Care Services Improvement Programme. Mental Health NSF Autumn Assessment 2007 – Dual Diagnosis Themed Review. London: Department of Health; 2008.
  19. National Institute for Health and Care Excellence (NICE). Coexisting Severe Mental Illness and Substance Misuse: Community Health and Social Care Services. London: NICE; 2016. [PubMed]
  20. Public Health England. Better Care for People with Co-occurring Mental Health and Alcohol/Drug Use Conditions – A Guide for Commissioners and Providers. London: Public Health England; 2017.
  21. NHS England. Community Mental Health Framework. London: Department of Health and Social Care; 2019.
  22. Home Office. From Harm to Hope. A 10 Year Drugs Plan to Cut Crime and Save Lives. London: HM Government; 2022. doi: 10.1016/j.drugpo.2022.103840. [DOI] [PubMed]
  23. Dame Carol Black. Review of Drugs Part Two: Prevention, Treatment, and Recovery. London: Department of Health and Social Care; 2021.
  24. Northern Ireland Department of Health. Preventing Harm, Empowering Recovery: A Strategic Framework to Tackle the Harm from Substance Use (2021–31). 2021.
  25. Population Health Directorate. Mental Health Strategy 2017–2022. Edinburgh: Scottish Government; 2017.
  26. Population Health Directorate. Rights, Respect and Recovery. Alcohol and Drug Treatment Strategy Edinburgh: Scottish Government; 2018.
  27. Health and Social Services. Substance Misuse Delivery Plan 2019–2022 ‘Improving Lives for People and Communities Affected by Substance Misuse’. Cardiff: Welsh Government; 2019.
  28. Pawson R, Tilley N. Realistic Evaluation. 1st edn. London: SAGE Publications Ltd; 1997.
  29. Wong G, Greenhalgh T, Westhorp G, Buckingham J, Pawson R. RAMESES publication standards: realist syntheses. BMC Med 2013;11(1):21. doi: 10.1186/1741-7015-11-21. [DOI] [PMC free article] [PubMed]
  30. Wong G, Westhorp G, Greenhalgh J, Manzano A, Jagosh J, Greenhalgh T. Quality and reporting standards, resources, training materials and information for realist evaluation: the RAMESES II project. Health Serv Deliv Res 2017;5:1–108. [PubMed]
  31. Shearn K, Allmark P, Piercy H, Hirst J. Building Realist Program Theory for Large Complex and Messy Interventions. Int J Qual Methods 2017;16(1). https://doi.org/10.1177/1609406917741796
  32. Booth A, Wright J, Briscoe S. Scoping and searching to support realist approaches. In: Emmel N, Greenhalgh T, Manzano A, Monaghan M, Dalkin S, editors. Doing Realist Research. London: SAGE Publications Ltd; 2018. pp. 147–66.
  33. Pawson R. Evidence Based Policy. London: SAGE Publications Ltd; 2006.
  34. Pawson R, Greenhalgh T, Harvey G, Walshe K. Realist synthesis: an introduction. ESRC Res Methods Program 2004;2.
  35. Booth A, Harris J, Croot E, Springett J, Campbell F, Wilkins E. Towards a methodology for cluster searching to provide conceptual and contextual ‘richness’ for systematic reviews of complex interventions: case study (CLUSTER). BMC Med Res Methodol 2013;13(1):118. doi: 10.1186/1471-2288-13-118. [DOI] [PMC free article] [PubMed]
  36. Monaghan M, Dalkin S, Emmell N, Greenhalgh J, Manzano A. Doing Realist Research. London: SAGE Publications Ltd; 2019.
  37. Byng R, Norman I, Redfern S. Using Realistic Evaluation to Evaluate a Practice-level Intervention to Improve Primary Healthcare for Patients with Long-term Mental Illness. Evaluation 2005;11(1):69–93. https://doi.org/10.1177/1356389005053198
  38. Manzano A. The craft of interviewing in realist evaluation. Evaluation 2016;22(3):342–60.
  39. Harris J, Dalkin S, Jones L, Ainscough T, Maden M, Bate A, et al. Achieving integrated treatment: a realist synthesis of service models and systems for 2 co-existing serious mental health and substance use conditions. Lancet Psychiatry 2023;108):632–43. doi: 10.1016/S2215-0366(23)00104-9. [DOI] [PubMed]
  40. Groenkjaer M, de Crespigny C, Liu D, Moss J, Cairney I, Lee D, et al. ‘The chicken or the egg’: barriers and facilitators to collaborative care for people with comorbidity in a metropolitan region of South Australia. Issues Ment Health Nurs 2017;38(1):18–24. doi: 10.1080/01612840.2016.1233596. [DOI] [PubMed]
  41. Pinderup P, Thylstrup B, Hesse M. Critical review of dual diagnosis training for mental health professionals. Int J Ment Health Addict 2016;14(5):856–72.
  42. Kay-Lambkin FJ, Baker AL, Lewin TJ. The ‘co-morbidity roundabout’: a framework to guide assessment and intervention strategies and engineer change among people with co-morbid problems. Drug Alcohol Rev 2004;23(4):407–23. doi: 10.1080/09595230412331324536. [DOI] [PubMed]
  43. Minkoff K. Developing welcoming systems for individuals with co-occurring disorders: the role of the comprehensive continuous integrated system of care model. J Dual Diagn 2004;1(1):65–89.
  44. Bell R. A multi-agency evaluation of the Leeds Dual Diagnosis care co-ordination protocol. Adv Dual Diagn 2014;7(4):162–84.
  45. Mee-Lee D. Treatment planning for dual disorders. Psychiatr Rehabil Ski 2001;5(1):52–79.
  46. Renner JA Jr, Quinones J, Wilson A. Training psychiatrists to diagnose and treat substance abuse disorders. Curr Psychiatry Rep 2005;7(5):352–9. doi: 10.1007/s11920-005-0035-2. [DOI] [PubMed]
  47. Danda MC. Attitudes of health care professionals towards addictions clients accessing mental health services: what do we know and how can this be used to improve care? J Ethics Mental Health 2012;7:1–5.
  48. Avery J, Dixon L, Adler D, Oslin D, Hackman A, First M, et al. Psychiatrists’ attitudes toward individuals with substance use disorders and serious mental illness. J Dual Diagn 2013;9(4):322–6.
  49. Graham HL. Coexisting severe mental health and substance use problems: developing integrated services in the UK. Psychiatric Bull 2004;27(5):183–6.
  50. Roberts BM, Maybery D. Dual diagnosis discourse in Victoria Australia: the responsiveness of mental health services. J Dual Diagn 2014;10(3):139–44. doi: 10.1080/15504263.2014.929332. [DOI] [PubMed]
  51. Canaway R, Merkes M. Barriers to comorbidity service delivery: the complexities of dual diagnosis and the need to agree on terminology and conceptual frameworks. Aust Health Rev 2010;34(3):262–8. doi: 10.1071/AH08723. [DOI] [PubMed]
  52. Hind A, Manley D. Stamp Out Stigma campaign: challenging attitudes to support and build a recovery-orientated ethos in substance misuse, mental health and dual diagnosis services. Adv Dual Diagn 2010;3(1):23–5.
  53. Lawrence-Jones J. Dual diagnosis (drug/alcohol and mental health): service user experiences. Practice 2010;22(2):115–31.
  54. Sorsa M, Greacen T, Lehto J, Astedt-Kurki P. A qualitative study of barriers to care for people with co-occurring disorders. Arch Psychiatr Nurs 2017;31(4):399–406. doi: 10.1016/j.apnu.2017.04.013. [DOI] [PubMed]
  55. Bjorkquist C, Hansen GV. Reducing service barriers to people with dual diagnosis in Norway. Cogent Soc Sci 2018;4(1):1561237.
  56. Annamalai A, Staeheli M, Cole RA, Steiner JL. Establishing an integrated health care clinic in a community mental health center: lessons learned. Psychiatr Q 2018;89(1):169–81. doi: 10.1007/s11126-017-9523-x. [DOI] [PubMed]
  57. Davidson L, Evans AC, Achara-Abrahams I, White W. Beyond co-occurring disorders to behavioral health integration. Adv Dual Diagn 2014;7(4):185–93.
  58. Hodges CL, Paterson S, Taikato M, McGarrol S, Crome I, Baldacchino A. Substance Misuse Research Co-morbid Mental Health and Substance Misuse in Scotland. Edinburgh: Scottish Executive; 2006.
  59. Barnes L, Rudge T. Co-operation and co-morbidity: managing dual diagnosis in rural South Australia. Collegian 2003;10(2):25–8. https://doi.org/10.1016/s1322-7696(08)60051-7 doi: 10.1016/s1322-7696(08)60051-7. [DOI] [PubMed]
  60. Manley DS. What helps and what hinders recovery: narratives of service users and practitioners about dual diagnosis (co-existing mental health and substance misuse problems). PhD thesis. Nottingham: University of Nottingham; 2015. URL: https://eprints.nottingham.ac.uk/30662 (accessed 19 August 2024).
  61. Louie E, Giannopoulos V, Baillie A, Uribe G, Byrne S, Deady M, et al. Translating evidence-based practice for managing comorbid substance use and mental illness using a multimodal training package. J Dual Diagn 2018;14(2):111–9. doi: 10.1080/15504263.2018.1437496. [DOI] [PubMed]
  62. Drake RE, Bond GR. Implementing integrated mental health and substance abuse services. J Dual Diagn 2010;6(3/4):251–62.
  63. Devitt TS, Davis KE, Kinley M, Smyth J. The evolution of integrated dual disorders treatment at thresholds: lessons learned. Am J Psychiatr Rehabili 2009;12(2):93–107.
  64. Blakely TJ, Dziadosz GM. Creating an agency integrated treatment program for co-occurring disorders. Am J Psychiatr Rehabili 2007;10(1):1–18.
  65. Hepner KA, Hunter SB, Paddock SM, Zhou AJ, Watkins KE. Training addiction counselors to implement CBT for depression. Adm Policy Ment Health 2011;38(4):313–23. doi: 10.1007/s10488-011-0359-7. [DOI] [PMC free article] [PubMed]
  66. Graham HL. Implementing integrated treatment for co-existing substance use and severe mental health problems in assertive outreach teams: training issues. Drug Alcohol Rev 2004;23(4):463–70. doi: 10.1080/09595230412331324581. [DOI] [PubMed]
  67. Boyle P, Wieder B. Creating and sustaining integrated dual diagnosis treatment programs: some lessons learned in Ohio. J Dual Diagn 2007;3(2):103–10.
  68. Leijten FRM, Struckmann V, van Ginneken E, Czypionka T, Kraus M, Reiss M, et al., SELFIE Consortium. The SELFIE framework for integrated care for multi-morbidity: development and description. Health Policy 2018;122(1):12–22. doi: 10.1016/j.healthpol.2017.06.002. [DOI] [PubMed]
  69. Baldacchino A, Greacen T, Hodges CL, Charzynska K, Sorsa M, Saias T, et al. Nature, level and type of networking for individuals with dual diagnosis: a European perspective. Drugs Educ Prev Policy 2010;18(5):393–401.
  70. Barreira P, Espey B, Fishbein R, Moran D, Flannery Jr RB. Linking substance abuse and serious mental illness service delivery systems: initiating a statewide collaborative. J Behav Health Serv Res 2000;27(1):107–13. doi: 10.1007/BF02287808. [DOI] [PubMed]
  71. Barrett P, Roberts S. Enhancing dual diagnosis capacities in acute inpatient nurses: a practitioner-based action research project. Adv Dual Diagn 2010;3(2):24–31.
  72. Anderson S, Hennessy C, Cornes M, Manthorpe J. Developing inter-disciplinary and inter-agency networks: reflections on a ‘community of practice’ approach. Adv Dual Diagn 2013;6(3):132–44.
  73. Biegel DE, Kola LA, Ronis RJ, Boyle PE, Delos Reyes CM, Wieder B, Kubek P. The Ohio substance abuse and mental illness coordinating center of excellence: implementation support for evidence-based practice. Res Soc Work Pract 2003;13(4):531–45.
  74. Clodfelter Jr RC, Albanese MJ, Baker G, Domoto K, Gui AL, Khantzian EJ. The MICA case conference program at Tewksbury Hospital, Massachusetts: an integrated treatment model. Am J Addict 2003;12(5):448–54. [PubMed]
  75. Swinden D, Barrett M. Developing a dual diagnosis role within mental health. Nurs Times 2008;104(19):26–7.
  76. Holland M. Substance use and mental health problems: meeting the challenge. Br J Nurs 1998;7(15):896–900. doi: 10.12968/bjon.1998.7.15.5619. [DOI] [PubMed]
  77. Engelhardt MA, Hills H, Monroe M. Comprehensive, continuous, integrated system of care development: Tampa-Hillsborough County, Florida. J Dual Diagn 2009;5(1):110–6.
  78. Bjorkquist C, Hansen GV. Coordination of services for dual diagnosis clients in the interface between specialist and community care. J Multidiscip Healthc 2018;11:233–43. doi: 10.2147/JMDH.S157769. [DOI] [PMC free article] [PubMed]
  79. Currie J. Review of dual diagnosis commissioning in the North West of England. Adv Dual Diagn 2011;4(3):135–40.
  80. Graham HL, Copello A, Birchwood M, Orford J, McGovern D, Georgiou G, et al. Service innovations: coexisting severe mental health and substance use problems: developing integrated services in the UK. Psych Bull 2003;27(5):183–6.
  81. Copello A, Graham H, Birchwood M. Evaluating substance misuse interventions in psychosis: the limitations of the RCT with ‘patient’ as the unit of analysis. J Ment Health 2001;10(6):585–7.
  82. Anastas T, Waddell EN, Howk S, Remiker M, Horton-Dunbar G, Fagnan LJ. Building behavioral health homes: clinician and staff perspectives on creating integrated care teams. J Behav Health Serv Res 2019;46(3):475–86. doi: 10.1007/s11414-018-9622-y. [DOI] [PMC free article] [PubMed]
  83. Chichester CS, Bepko C, Ogden J, Hornby H, McAuley K. Implementing an integrated system of care model in the state of Maine. J Dual Diagns 2009;5(3/4):436–46.
  84. Scottish Drug Deaths Taskforce. Changing Lives. Final Report. Edinburgh: Scottish Government; 2022.
  85. Graham HL, Copello A, Griffith E, Freemantle N, McCrone P, Clarke L, et al. Pilot randomised trial of a brief intervention for comorbid substance misuse in psychiatric in-patient settings. Acta Psychiatr Scand 2016;133(4):298–309. doi: 10.1111/acps.12530. [DOI] [PMC free article] [PubMed]
  86. Center for Substance Abuse Treatment. Chapter 2, Building a Trauma-informed Workforce. In Trauma-Informed Care in Behavioral Health Services. Vol. 57. Rockville, MD: Center for Substance Abuse Treatment; 2014.
  87. National Improvement and Leadership Development Board. Developing People – Improving Care. A National Framework for Action on Improvement and Leadership Development in NHS-funded Services. NHS England; 2010.
  88. NHS Confederation. Running Hot: The Impact of the Pandemic on Mental Health Services. NHS Confederation; 2022.

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