Article title: Systematic analysis of Fc mutations designed to reduce binding to Fc-gamma receptors
Authors: Geoff Hale, Jelle De Vos, Alastair Douglas Davy, Koen Sandra and Ian Wilkinson
Journal: mAbs
DOI: https://doi.org/10.1080/19420862.2024.2402701
The author has identified a correction in Table 1 row 6, entry mAb-028: The figure 6 under “Number of INNs” to be replaced by 0 instead of the value 6. The corrected table 1 has been placed below.
Also, in page 6 in the sentence “Besides STR, the only IgG1 variant to completely eliminate FcγR binding was F233Δ/L234Δ/L235Δ” the value F233Δ has been corrected as E233Δ.
The corrected sentence will appear in the article as “Besides STR, the only IgG1 variant to completely eliminate FcγR binding was E233Δ/L234Δ/L235Δ”.
| Sample number | Isotype | Mutations | Number of INNs | IMGT Code | Citation | doi |
|---|---|---|---|---|---|---|
| mAb-024 | IgG1 | 402 | ||||
| mAb-075 | IgG1 | E233del L234del L235del | 0 | G1v65 | ||
| mAb-029 | IgG1 | E233P L234V L235A | 1 | Armour 1999 | 10.1002/(SICI)1521-4141(199908)29:08<2613::AID-IMMU2613>3.0.CO;2-J | |
| mAb-030 | IgG1 | E233P L234V L235A G236del | 0 | G1v50 | Armour 1999 | 10.1002/(SICI)1521-4141(199908)29:08<2613::AID-IMMU2613>3.0.CO;2-J |
| mAb-027 | IgG1 | E233P L234A L235A G236del P329A | 2 | |||
| mAb-028 | IgG1 | E233P L234V G236del S267K | 0 | |||
| mAb-033 | IgG1 | L234A L235A | 28 | G1v14 | Xu 2000 | 10.1006/cimm.2000.1617 |
| mAb-034 | IgG1 | L234A L235A G237A | 7 | G1v14-1 | Bloom 2009 | Patent application WO2009143536 |
| mAb-066 | IgG1 | L234A L235A G237A P238S H268A A330S P331S | 0 | Tam 2017 | 10.3390/antib6030012 | |
| mAb-036 | IgG1 | L234A L235A G237A N297A | 1 | |||
| mAb-035 | IgG1 | L234A L235A G237A K322A | 1 | Hernandez-Hoyos 2016 | 10.1158/1535-7163.MCT-15-024 | |
| mAb-061 | IgG1 | L234A L235A D265A | 0 | |||
| mAb-056 | IgG1 | L234A L235A D265S | 1 | G1v14-67 | Edavettal 2022 | 10.1016/j.medj.2022.09.007 |
| mAb-062 | IgG1 | L234A L235A K322A | 0 | Lin 2013 | 10.4161/cbt.26106 | |
| mAb-068 | IgG1 | L234A L235A L328R | 0 | G1v14-48 | ||
| mAb-057 | IgG1 | L234A L235A P329A | 0 | G1v14-4 | ||
| mAb-037 | IgG1 | L234A L235A P329G | 10 | G1v14-49 | Schlothauer 2016 | 10.1093/protein/gzw040 |
| mAb-058 | IgG1 | L234A L235A P329S | 0 | |||
| mAb-038 | IgG1 | L234A L235A P331S | 1 | G1v40 | Kurnellas 2023 | 10.1186/s12967-023-04251-y |
| mAb-039 | IgG1 | L234A L235E | 1 | |||
| mAb-040 | IgG1 | L234A L235E G237A | 3 | G1v43 | Latour 2001 | 10.4049/jimmunol.167.5.2547 |
| mAb-041 | IgG1 | L234A L235E G237A A330S P331S | 4 | Li 2018 | 10.1186/s40425-018-0329-7 | |
| mAb-042 | IgG1 | L234A L235Q K322Q | 1 | Alvarado 2022 | 10.1111/all.15262 | |
| mAb-031 | IgG1 | L234A G237A | 1 | Bloom 2009 | Patent application WO2009143526 | |
| mAb-032 | IgG1 | L234A G237A A330V | 1 | |||
| mAb-043 | IgG1 | L234F L235E D265A | 3 | Engleberts 2020 | 10.1016/j.ebiom.2019.102625 | |
| mAb-044 | IgG1 | L234F L235E P331S | 7 | G1v39 | Oganesyan 2008 | 10.1107/S0907444908007877 |
| mAb-064 | IgG1 | L234F L235Q K322Q | 0 | G1v53 | Borrok 2017 | 10.1002/eji.1830230216 |
| mAb-067 | IgG1 | L234S L235T G236R | 0 | G1v59 | Wilkinson 2021 | 10.1371/journal.pone.0260954 |
| mAb-045 | IgG1 | L235A G237A | 4 | Frewin 2002 | Patent application WO2002102853 | |
| mAb-069 | IgG1 | L235E | 0 | G1v23 | Alegre 1992 | 10.4049/jimmunol.148.11.3461 |
| mAb-046 | IgG1 | L235G G236R | 1 | Geuijen 2018 | 10.1016/j.ccell.2018.04.003 | |
| mAb-055 | IgG1 | L235R G236R S239K A327G A330S P331S | 1 | |||
| mAb-063 | IgG1 | G236R L328R | 0 | G1v52 | Horton 2008, Chu 2008 | 10.1158/0008-5472.CAN-08-2268 |
| mAb-074 | IgG1 | P238S | 0 | G1v63 | ||
| mAb-059 | IgG1 | D265A | 0 | G1v66 | Shields 2001 | 10.1074/jbc.M009483200 |
| mAb-026 | IgG1 | D265A P329A | 1 | |||
| mAb-060 | IgG1 | D265S | 0 | G1v67 | ||
| mAb-072 | IgG1 | S267K | 0 | G1v51 | ||
| mAb-054 | IgG1 | V273E | 1 | Ye 2019 | 10.1158/2326-6066.CIR-18-0805 | |
| mAb-047 | IgG1 | N297A | 12 | G1v29 | Bolt 1993 | 10.1002/eji.1830230216 |
| mAb-048 | IgG1 | N297A K322A | 1 | Hoseini 2018 | 10.1158/0008-5472.CAN-08-2268 | |
| mAb-049 | IgG1 | N297G | 16 | G1v30 | Leabman 2013 | 10.4161/mabs.26436 |
| mAb-050 | IgG1 | N297H | 1 | Tao 1989 | 10.4049/jimmunol.143.8.2595 | |
| mAb-051 | IgG1 | N297Q | 2 | G1v36 | Tao 1989 | 10.4049/jimmunol.143.8.2595 |
| mAb-052 | IgG1 | N297S | 1 | He 2013 | 10.4049/jimmunol.1300409 | |
| mAb-065 | IgG1 | S298N T299A Y300S | 0 | Zhou 2020 | 10.1080/19420862.2020.1814583 | |
| mAb-053 | IgG1 | T299A | 1 | Sazinsky 2008 | 10.1073/pnas.0809257105 | |
| mAb-070 | IgG1 | L328R | 0 | G1v48 | ||
| mAb-071 | IgG1 | P329G | 0 | G1v49 | Schlothauer 2016 | 10.1093/protein/gzw040 |
| mAb-073 | IgG1 | A330S P331S | 0 | G1v60 | ||
| mAb-025 | IgG1 | A330V | 2 | Knopf 2007 | Patent application WO2007062188 | |
| mAb-001 | IgG2 | 42 | ||||
| mAb-008 | IgG2 | V234A G237A | 2 | Cole 1997 | 10.4049/jimmunol.159.7.3613 | |
| mAb-009 | IgG2 | V234A G237A P238S H268A V309L A330S P331S | 1 | G2v3 | Vafa 2014 | 10.1016/j.ymeth.2013.06.035 |
| mAb-011 | IgG2 | V234S A235T del236R | 0 | Wilkinson 2021 | 10.1371/journal.pone.0260954 | |
| mAb-005 | IgG2 | D265A A330S P331S | 1 | Bloom 2009 | Patent application WO2009143526 | |
| mAb-076 | IgG2 | H268Q V309L A330S P331S | 0 | G2v2 | An 2009 | 10.1111/all.15262 |
| mAb-006 | IgG2 | F296A N297Q | 0 | |||
| mAb-007 | IgG2 | K322A | 1 | |||
| mAb-004 | IgG2 | A330S P331S | 5 | Armour 1999 | 10.1002/(SICI)1521-4141(199908)29:08<2613::AID-IMMU2613>3.0.CO;2-J | |
| mAb-010 | IgG2 | P331S | 2 | Yan 2011 | Patent application W2011147319 | |
| mAb-002 | IgG2/1 | F296A N297Q | 1 | Goodman 2009 | Patent application WO2009010290 | |
| mAb-003 | IgG2/4 | 4 | G2G4v1 | Mueller 1997 | 10.1016/S0161-5890(97)00042-4 | |
| mAb-022 | IgG3 | 1 | ||||
| mAb-023 | IgG3 | L234S L235T G236R | 0 | Wilkinson 2021 | 10.1371/journal.pone.0260954 | |
| mAb-012 | IgG4 | 29 | Bruggemann 1987 | 10.1084/jem.166.5.1351 | ||
| mAb-013 | IgG4-P | 95 | Angal 1993 | 10.1016/0161-5890(93)90432-B | ||
| mAb-018 | IgG4-P | E233P F234V L235A G236del | 4 | Armour 1999 | 10.1002/(SICI)1521-4141(199908)29:08<2613::AID-IMMU2613>3.0.CO;2-J | |
| mAb-017 | IgG4-P | E233P F234V L235A D265A | 1 | Zhang 2018 | 10.1007/s00262-018-2160-x | |
| mAb-014 | IgG4-P | F234A L235A | 17 | G4v4 | Alegre 1994 | 10.1097/00007890-199457110-00001 |
| mAb-020 | IgG4-P | F234A L235A G237A P238S | 0 | Tam 2017 | 10.3390/antib6030012 | |
| mAb-021 | IgG4-P | F234S L235T G236R | 0 | Wilkinson 2021 | 10.1371/journal.pone.0260954 | |
| mAb-015 | IgG4-P | L235A | 1 | Smith 2008 | Patent application WO2008129124 | |
| mAb-016 | IgG4-P | L235E | 8 | G4v3 | Alegre 1992 | 10.4049/jimmunol.148.11.3461 |
| mAb-077 | IgG4-P | L235E P329G | 0 | G4v3-49 | Schlothauer 2016 | 10.1093/protein/gzw040 |
| mAb-019 | IgG4-P | N297Q | 1 | G4v36 | Schlothauer 2016 | 10.1093/protein/gzw040 |