Abstract
High-field 1H-n.m.r.-spectroscopic studies supported by chemical carbohydrate analyses show that skeletal keratan sulphates (KS-II) of bovine origin may be sub-classified into two groups. Keratan sulphate chains from articular and intervertebral-disc cartilage (KS-II-A) contain two structural features, namely alpha(1----3)-fucose and alpha(2----6)-linked N-acetyl-neuraminic acid residues, that are absent from keratan sulphates from tracheal or nasal-septum cartilage (KS-II-B).
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Antonsson P., Heinegård D., Oldberg A. The keratan sulfate-enriched region of bovine cartilage proteoglycan consists of a consecutively repeated hexapeptide motif. J Biol Chem. 1989 Sep 25;264(27):16170–16173. [PubMed] [Google Scholar]
- Bray B. A., Lieberman R., Meyer K. Structure of human skeletal keratosulfate. The linkage region. J Biol Chem. 1967 Jul 25;242(14):3373–3380. [PubMed] [Google Scholar]
- Dickenson J. M., Huckerby T. N., Nieduszynski I. A. Two linkage-region fragments isolated from skeletal keratan sulphate contain a sulphated N-acetylglucosamine residue. Biochem J. 1990 Jul 1;269(1):55–59. doi: 10.1042/bj2690055. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Heinegård D., Axelsson I. Distribution of keratan sulfate in cartilage proteoglycans. J Biol Chem. 1977 Mar 25;252(6):1971–1979. [PubMed] [Google Scholar]
- Honda S., Takahashi M., Kakehi K., Ganno S. Rapid, automated analysis of monosaccharides by high-performance anion-exchange chromatography of borate complexes with fluorimetric detection using 2-cyanoacetamide. Anal Biochem. 1981 May 1;113(1):130–138. doi: 10.1016/0003-2697(81)90055-5. [DOI] [PubMed] [Google Scholar]
- Krusius T., Finne J., Margolis R. K., Margolis R. U. Identification of an O-glycosidic mannose-linked sialylated tetrasaccharide and keratan sulfate oligosaccharides in the chondroitin sulfate proteoglycan of brain. J Biol Chem. 1986 Jun 25;261(18):8237–8242. [PubMed] [Google Scholar]
- Lohmander L. S. Analysis by high-performance liquid chromatography of radioactively labeled carbohydrate components of proteoglycans. Anal Biochem. 1986 Apr;154(1):75–84. doi: 10.1016/0003-2697(86)90498-7. [DOI] [PubMed] [Google Scholar]
- Plaas A. H., Ison A. L., Ackland J. Synthesis of small proteoglycans substituted with keratan sulfate by rabbit articular chondrocytes. J Biol Chem. 1989 Aug 25;264(24):14447–14454. [PubMed] [Google Scholar]
- Thornton D. J., Morris H. G., Cockin G. H., Huckerby T. N., Nieduszynski I. A., Carlstedt I., Hardingham T. E., Ratcliffe A. Structural and immunological studies of keratan sulphates from mature bovine articular cartilage. Biochem J. 1989 May 15;260(1):277–282. doi: 10.1042/bj2600277. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thornton D. J., Morris H. G., Cockin G. H., Huckerby T. N., Nieduszynski I. A. Structural studies of two populations of keratan sulphate chains from mature bovine articular cartilage. Glycoconj J. 1989;6(2):209–218. doi: 10.1007/BF01050649. [DOI] [PubMed] [Google Scholar]