Rapid CD4⁺ T-Cell Loss Induced by Human Immunodeficiency Virus Type 1_NC in Uninfected and Previously Infected Chimpanzees

Volume 75, no. 3, p. 1533–1539, 2001. It has been brought to our attention that the chimpanzee referred to as uninfected in this article (C534), while uninfected with HIV-1, was previously inoculated with HIV-2. C534 demonstrated a low-level serological reactivity to HIV-2 prior to infection with HIV-1_NC, but virus was never recovered from PBMC. Despite the absence of cross-reactive antibodies to HIV-1 prior to HIV-1_NC inoculation, the prior infection of C534 with HIV-2 may have influenced the kinetics of HIV-1 seroconversion in this animal.