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. 1991 Feb 1;273(Pt 3):803–806. doi: 10.1042/bj2730803

Inhibition of a receptor-operated calcium channel in pig aortic microsomes by cyclic GMP-dependent protein kinase.

L M Blayney 1, P W Gapper 1, A C Newby 1
PMCID: PMC1149835  PMID: 1705117

Abstract

We have further characterized a putative receptor-operated Ca2+ channel that is activated by histamine and guanosine 5'-[beta gamma-imido]triphosphate. Insensitivity to verapamil, diltiazem or nicardipine, but inhibition by Ni2+ and SK&F 96365, further identify the channel with receptor-mediated Ca2+ entry in intact cells. Inhibition of the channel by cyclic-GMP-dependent protein kinase may contribute to vascular relaxation in response to nitrovasodilators.

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Selected References

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