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. 1991 Jan 15;273(Pt 2):477–479. doi: 10.1042/bj2730477

Expression of c-jun, jun B and jun D proto-oncogenes in human peripheral-blood granulocytes.

F Mollinedo 1, M J Vaquerizo 1, J R Naranjo 1
PMCID: PMC1149869  PMID: 1899335

Abstract

We have found that purified human peripheral-blood granulocytes express constitutively significant levels of proto-oncogenes c-jun, jun B and jun D mRNA. Upon functional activation of granulocytes by 4 beta-phorbol 12-myristate 13-acetate (PMA), the levels of c-jun, jun B and jun D transcripts were increased. The three jun genes showed a similar time course in their induction by PMA, maximal mRNA levels being reached after 60 min of induction. These results suggest that expression of c-jun, jun B and jun D genes might be involved in terminal granulocyte differentiation or in regulating granulocyte functionality.

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Selected References

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