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. 2024 Oct 24;19(10):e0295545. doi: 10.1371/journal.pone.0295545

Mental health issues and the association of mental health literacy among adolescents in urban Ethiopia

Hailemariam Mamo Hassen 1,*, Manas Ranjan Behera 2, Deepanjali Behera 2, Ranjit Kumar Dehury 3
Editor: Yared Reta Abayneh4
PMCID: PMC11500858  PMID: 39446875

Abstract

Background

Epidemiological evidence about the prevalence of adolescent mental health issues and their association with mental health literacy is crucial for sustained mental health promotion strategies. Adolescence is a critical life stage for mental health promotion. However, evidence is not available among Ethiopian school adolescents. Hence, the present study examined the prevalence of adolescents’ mental health issues and their correlation with mental health literacy.

Materials and methods

A cross-sectional study was conducted among adolescents (grades 5–12) in Dire Dawa city, Eastern Ethiopia using multistage random sampling. Data was collected using the Strength and Difficulty Questionnaire, WHO-5 well-being index, and mental health literacy questionnaire. SPSS version 25 was used for the descriptive, Chi-square, binary logistic regression, and correlation analyses.

Results

Between 14.0–24.5% of adolescents had reported mental health problems: internalizing problems (14.9–28.8%), emotional problems (10.4–25.5%), and peer relationship problems (17.8–25.5%). These mental health problems were significantly greater among adolescents who had either themselves or their family members used psychoactive substances (p≤0.05). Females from upper elementary (5–8 grade) and lower secondary (9–10) grade levels had a higher prevalence of mental health problems (AOR: 2.60 (0.95–7.10, p<0.05)). The effect of age, parental education, or employment status was insignificant (p>0.05). The prevalence of depression ranged from 18.0–25.5%. Mental health literacy was negatively correlated with total difficulties scores and positively associated with mental well-being scores (p<0.05).

Conclusion

The prevalence of adolescents’ mental health problems was higher. It implied that promoting mental health literacy could enhance adolescents’ positive mental health. Intervention programs should prioritize vulnerable groups and individuals reporting symptoms of mental health difficulties. Future studies should involve qualitative studies and consider effect of other determinants.

1. Introduction

Globally, mental health problems disproportionately affect adolescents in low-income countries and they remain the leading causes of disease burden among children and young people [1]. Knowing about these mental health conditions, their symptoms, and treatments termed as mental health literacy is essential for everyone but is crucial for adolescents [2]. Mental health literacy is defined as understanding and applying information about mental health [2]. In this regard, much has been known about the mental health literacy of adolescents from high-income countries [3]. However, it is still a relatively new concept in Africa [2]. Additionally, studies revealed that access to mental health information or services in Africa is lower due to poverty, lack of education, and cultural stigma around mental illness [1]. Nevertheless, limited evidence in Africa, including Ethiopia, has indicated a growing awareness about the importance of mental health literacy. Despite the challenges associated with poverty, cultural stigma, lack of access to health facilities, and lower education coverage, countries are working to improve mental health literacy [2].

The Ethiopian Ministry of Health has developed a mental health policy focusing on primary mental healthcare and promoting positive mental health, including a mental health awareness campaign [4]. The present study area is Dire Dawa, one of Ethiopian provinces known for its ethnic and cultural language diversity. A recent study revealed that adolescent mental health literacy from Dire Dawa city was lower, consistent with similar studies reports and showing variability across socio-demographic factors [5].

Epidemiological evidence about the prevalence of mental health problems and their association with mental health literacy is crucial for sustained mental health promotion strategies, as adolescence is a critical life stage for mental health promotion [610]. However, such evidence is rarely available among Ethiopian school adolescents. Adolescent mental health has piqued the interest of public health professionals due to the unique nature of adolescence [11]. Therefore, adolescence remains a critical life stage for mental health promotion [11]. A popular saying goes, “there is no health without mental health” [12]. With multifaceted burdens, mental health is integrally linked to physical health and well-being [13]. The typical adolescent mental health problems include but are not limited to substance use/abuse or disorders, depression/mood disorders, anxiety, schizophrenia, stress/neurosis, behavioral disorders, postpartum psychosis, and posttraumatic stress disorder (PTSD) [14, 15]. Several studies showed that these mental health problems in adulthood occur during adolescence [14, 15].

For multiple reasons, adolescents are among the most important groups for mental health studies. For example, adolescence is key to physical, emotional, and cognitive progress [11, 16, 17]. Fundamentally, mental, physical, and emotional developmental processes evolve during adolescence [18]. Also public health perspectives emphasizing mental health information during early childhood, [18] would help in later life in managing and preventing mental health problems [18].

Mental health literacy is essential to preventing mental illnesses, consisting of knowledge about mental health problems and recognizing illnesses with their symptoms [1, 3]. Studying the mental health status and its association with the mental health literacy of adolescents is paramount because it helps understand these variables across varied cultural settings [1]. The peak of the onset of mental disorders mainly occurs in the adolescent period and needs urgent attention [19]. In low-resource countries like Ethiopia, risk factors such as cigarette smoking, alcohol consumption, early cohabitation, unhealthy lifestyles etc, are higher among adolescents [20, 21]. leading to various mental health problems [11, 16, 17]. Hence, epidemiological methods like cross-sectional studies provide empirical evidence about the mental health status and factors that contribute to mental health problems [22]. Early understanding of this evidence contribute for making informed and effective interventions to improve adolescents’ mental health [23]. As a result, there is an increasing demand for adolescents’ mental health and well-being outcome measures to inform the public and policymakers regarding individual or service-level health promotion and therapeutic practices [24]. In this regard, the Strength Difficulties Questionnaire (SDQ) and the Mental Well-being Index (WHO-5) have been essential to meet the criteria of valid and reliable measures.

The assessment of mental health issues using the familiar Diagnostic Standard Manual– 5 (DSM-5) and International Classification of Disease (ICD-11) analysis has been published in previous studies [25, 26]. Such an approach is marked by clustering disorders, namely, externalizing and internalizing problems. Instruments with high validity are routinely used to measure the internalizing groups (i.e., depressive, somatic, and anxiety symptoms) and the externalizing groups (substance use, disruptive, and conduct symptoms). Furthermore, the well-being state was examined using the WHO-5 index, with lower scores indicating depression.

The daily suffering of people with mental illness affects family members, mainly children, and adolescent populations [27]. Globally, about 25% of the total population and 10–20% of children and adolescents have mental disorders, of which half of all these mental health problems begin by the age of fourteen and three-fourths by the age of early twenties [28, 29]. A worldwide-pooled prevalence meta-analysis on mental disorders from all regions of the world addressing 27 countries showed a prevalence of 13.4% ranging from 11.3 to 15.9 (CI: 95%), which indicates mental disorders are affecting a large proportion of the child and adolescent population [30]. According to studies that used the strengths and difficulties questionnaire (SDQ), around 10.5% (5.8–15%) of adolescents in developing countries had mental health concerns [31].

The prevalence of mental health problems among adolescents in Africa including Ethiopia, was reportedly higher [3236]. For instance, a meta-analysis study on adolescents in sub-Saharan Africa, including Ethiopia (N = 9713), showed the proportion of adolescents having psychopathology was 14.3% (13.6%-15.0%), and the prevalence of psychological disorders was 19.8% (18.8%-20.7%) [34]. These mental health problems are exacerbated by modifiable factors such as low mental health service seeking, lower mental health service use, stigma, discrimination, and common human rights abuses. These factors are linked to immediate and intermediate mental health outcomes such as health literacy and behaviour. Mental health literacy is a changeable factor linked to improved psychological outcomes [610]. It refers to how well a person understands mental diseases and the associated factors [610]. Mental health literacy includes an individual’s potential to identify mental distress [9, 3739]. Some qualitative descriptions revealed that mental health difficulties and mental well-being are associated with mental health literacy, despite the lack of quantitative evidence of the correlation between mental health literacy, mental health status, and mental well-being [30].

There has been a scarcity of available epidemiological evidence about mental health conditions and literacy among Ethiopian school adolescents. There was also a lack of evidence about school adolescents’ mental health status and the effect of socio-demographic characteristics in the existing literature. Therefore, the objectives of the study were:

  • To assess the prevalence of mental health issues among urban adolescents in Ethiopia

  • To evaluate the relationship between mental health literacy and mental health issues and

  • To examine the association between socio-demographic characteristics and mental health issues

2. Materials and methods

2.1. Study design and sampling

The present research was a cross-sectional study among public and private school adolescents in grades 5 through 12 from 11 to 19 years in Dire Dawa, Ethiopia. A combination of multistage (schools, classrooms, then individual students) and systematic and random (using the list of the students in fixed intervals of their roll numbers) was used to select study participants from public and private schools. The prevalence of self-reported mental health difficulty was obtained from the pilot study of the same population (p = 0.378) [40], and the margin of sampling error (d = 0.04) was taken to calculate the sample size.

n(Za/2)2xP(1P)d2=1.962x0.378(10.378)0.042=559.673560

Data was collected from June 2020 to July 2020 using the mental health literacy questionnaire (MHLQ), the Strength and Difficulty Questionnaire (SDQ), and the WHO-5 well-being index after cross-cultural validation in the study settings. Maximum sample size estimation (n = 924) was approached after taking design effect (d = 1.5) and a 10% non-response. Eighty one percent of potential participants (n = 751) filled out the questionnaires out of the 924 potential participants.

2.2. Data collection tools

Data collection tools were the Strengths and Difficulties Questionnaire (SDQ), mental health literacy questionnaire (MHLQ), and mental well-being index (WHO-5). The predictor variables mainly focusing on age, grade level, self or any family member experience with psychoactive substance use, parents practising corporal punishment, perceived worry about family problems, parents’ education, and job status were collected by using questionnaires. The Strengths and Difficulties Questionnaire (SDQ) is a valid, rapid measure for emotional and behavioral problems worldwide [31, 4144]. The SDQ is a 25-item self-report questionnaire that assesses five mental health domains: conduct problems, emotional symptoms, peer problems, hyperactivity-inattention, and pro-social behavior [31, 4144]. It is a 25-item, 3-point Likert scale (0 = not true, 1 = somewhat true, and 2 = certainly true). It measures subscale difficulty problems that are emotional(SDQ3,8,13,16&24), conduct (SDQ5,7,12,18&22), hyperactivity/inattention(SDQ 2,10,15,21&25), peer(SDQ6,11,14,19&23) and pro-social behaviour (SDQ 1,4,9,17&20) problems [45]. The total difficulties score combines conduct, hyperactivity, emotional, and peer relationship behaviour problems. The externalizing problem manifests emotional and peer behavioural relationship problems. Meanwhile, the internalizing problem manifests the conduct and hyperactivity/inattention problems.

Adding up the first four subscales leads to total difficulty scores (the higher the total difficulties score, the more significant the mental health difficulty) [45]. The fifth sub-scale of the SDQ reflects pro-social behaviour (the higher the score, the better the pro-social behaviour) [45]. SDQ is widely used in resource-poor countries to measure children and adolescents’ mental and emotional problems. The baseline for cut-off scores, which defined total and subscales strength and difficulty scores were from the United Kingdom population norms defined during the instrument development [43, 46]. The self-administered SDQ is a validated and widely used measurement tool for determining mental health problems in children and adolescents [31, 4144]. It has already been translated into over 60 languages, including Ethiopian Amharic [31, 4144]. It has reportedly been an effective tool for assessing children’s mental health in a recent scoping review in Africa [47].

Mental health literacy was measured using the mental health literacy questionnaire (MHLQ). This MHLQ tool is freely available and validated for adults, [48] and adolescents [7, 39, 4956] living in low-income countries to measure health literacy scores. In the context of the current investigation, its reliability was evaluated using Cronbach’s alpha and found to be 0.834. MHLQ has 33 items with five Likert scale ratings (1 = strongly disagree, 2 = slightly disagree, 3 = neither agree nor disagree, 4 = slightly agree, 5 = strongly agree). The MHLQ consists of 33 questions that measure factors like recognition (10 questions), knowledge (8 questions), attitudes (8 questions), and beliefs (7 questions) of the adolescents on mental health status [610]. The range of scores for the mental health literacy tool is 33 to 165. A higher score implies a better level of mental health literacy.

The mental well-being index (WHO-5) is an overarching expression of the quality of the various domains in the life of adolescents subjective to their mental and psychological well-being. Mental well-being was assessed using the WHO’s well-being index, which consists of 5 items (WHO-5) [5762]. It is a Likert-type scale with a five-point scale (5 = all of the time, 4 = most of the time, 3 = more than half the time, 2 = less than half the time, 1 = some of the time, 0 = at no time).

2.3. Ethical approval

Ethical approval was obtained from KIIT University, Bhubaneswar, India and Haramaya University, Ethiopia. Written informed consent was obtained from all participants. Written informed consent was obtained from parents of adolescents aged under fifteen years had offered their consent and adolescents of fifteen and above years was factored out following the school counsellors and school principals’ adequate explanation about their level of maturity and decisional capacity. As a duly authorized representative, written informed consent was obtained from school principals.

2.4. Statistical analysis

SPSS version 25 was used to carry out the statistical analysis. Descriptive analysis was performed to present the socio-demographic characteristics, cut-off score determination, and prevalence of mental health problems. Chi-square test and binary logistic regression analysis were used to estimate the difference and compare the mental health problems prevalence between males and females across some socio-demographic characteristics. Correlation analysis was performed to assess the associations between mental health literacy, strength difficulties questionnaire scale, and subjective mental well-being. Estimates used a confidence interval of 95% (p≤0.05).

The cut-off score for mental health problems(cases) was defined using the original 3 band categorizations (cut-off scores at 80th & 90th) [6365]. Scores of every item in the scale are added from 0–10. The added scores (range of 0–40) were calculated by adding scores on the emotion components, conduct problems, hyperactivity, inattention, and peer problem scales [31, 43, 44]. The cut-off scores was defined by percentile into the highest first 10% (abnormal), the next 10% (borderline), and the remaining 80% (normal). The cut-off for mental health problems (caseness) was the highest at first 10%.

3. Results

3.1. The socio-demographic characteristics of study participants

The socio-demographic characteristics of study participants are presented in Table 1. The study included 731 adolescents (366 males, 365 females) aged 11–19 years old, with a mean age of 16.11 years. The majority of participants were from middle adolescent age groups (40.6%), followed by late adolescents (46.1%) and early adolescents (13.3%). Most participants had at least a secondary education level (71.2%), and a majority were not using psychoactive substances (89.7%).

Table 1. Descriptive statistics of socio-demographic characteristics stratified by gender and mean age.

Socio-demographic Characteristics Male n (%) Female n(%) Total n(%) Age in years
Mean ± SD
All Participants 366(50.1) 365(49.9) 731(100) 16.11±2.11
Age group(years)
Early adolescents(11–13) 50(13.7) 47(12.9) 97(13.3) 12.43±0.67
Middle adolescents(14–16) 134(36.6) 163(44.7) 297(40.6) 15.15±0.80
Late adolescents(17–19) 182(49.7) 155(42.5) 337(46.1) 18.01±0.81
Grade level
Upper elementary (Grade 5–8) 144(39.3) 157(43.0) 301(41.2) 14.38±1.78
Lower Secondary (Grade 9–10) 145(39.6) 146(40.0) 291(39.8) 16.88±1.30
Upper secondary (Grade 11–12) 77(21.0) 62(17.0) 139(19.0) 18.24±0.87
Self-experience on psychoactive substances use
No 318(48.48) 338(51.52) 656(89.74) 16.04±2.11
Yes 48(64.00) 27(36.00) 75(10.26) 16.76±2.00
Any family experience on psychoactive substances use
No 253(72.86) 271(70.44) 524(77.12) 15.99±2.14
Yes 95(27.14) 113(29.66) 208(22.88) 16.64±1.99
Parents practicing corporal punishment
No 120(48.26) 134(51.74) 254(65.70) 16.08±2.08
Yes 129(57.33) 96(42.67) 225(34.30 16.50±1.98
Adolescents report perceived worry about family problem
No 110(47.83) 120(52.17) 230(31.46) 15.62±2.28
Yes 256(51.10) 245(48.90) 501(68.54) 16.34±1.99
Mother education level
Non-educated 233(63.7) 221(60.5) 454(62.1) 16.15±2.16
Elementary Level 31(8.5) 34(9.3) 65(8.9) 16.78±1.94
Secondary level 73(19.9) 86(23.6) 159(21.8) 15.96±2.04
College or above 29(7.9) 24(6.6) 53(7.3) 15.42±1.91
Father education level
Non-educated 200(54.6) 198(54.2) 398(54.4) 16.19±2.16
Elementary Level 21(5.7) 9(2.5) 30(4.1) 17.00±1.55
Secondary level 90(24.6) 103(28.2) 193(26.4) 15.85±2.10
Diploma/Certificate or above 55(15.0) 55(15.1) 110(15.0) 16.05±2.01
Mother Job
Housewife Or Unemployed 129(45.9) 153(53.1) 282(49.6) 16.39±2.07
Work in private 106(37.7) 91(31.6) 197(34.6) 16.13±2.00
Employed 46(16.4) 44(15.3) 90(15.8) 15.38±2.23
Father Job
Unemployed/Jobless 13(3.6) 6(1.6) 19(2.6) 17.26±1.45
Work in private 257(70.2) 256(70.1) 513(70.2) 16.17±2.10
Employed 96(26.2) 103(28.2) 199(27.2) 15.84±2.15

3.2. Strength difficulty scores and prevalence of mental health status

The original 3 bands (cut-off scores at 80th & 90th) and the newer 4 band (cut-off scores at 80th, 90th & 95th) categorization were reported just for comparison as reported in Table 2. The original 3 band was used to determine and estimate adolescents’ mental health issues. The mental health problems expressed with the total difficulties and in subscales, in general, were higher for female adolescents than male adolescents. The prevalence of mental health problems (cases) was presented across gender and age categories.

Table 2. The cut of scores for baseline reference ranges (caseness) for both the original 3 band and the newer 4 band categorizations.


Self-completed SDQ
Original 3 band categories(cut-off scores at 80th & 90th) Newer 4 band categorisations (cut-off scores at 80th, 90th & 95th)
Normal Borderline Abnormal Close to average Slightly raised
slightly lowered

High (/low)
Very high (/very low
Baseline norm Present study range Baseline norm Present study range Baseline norm Present study range Baseline norm Present study range Baseline norm Present study range Baseline norm Present study range Baseline norm Present study range
Total difficulties score 0–15 0–14 16–19 15–17 20–40 18–40 0–14 0–14 15–17 15–17 18–19 18–20 20–40 20–40
Emotional problems score 0–5 0–5 6 6 7–10 7–10 0–4 0–5 5 6 6 7 7–10 8–10
Conduct problems score 0–3 0–3 4 4 5–10 5–10 0–3 0–3 4 4 5 5 6–10 6–10
Hyperactivity score 0–5 0–4 6 5 7–10 6–10 0–5 0–4 6 5 7 6 8–10 7–9
Peer problems score 0–3 0–4 4–5 5 6–10 6–10 0–2 0–4 3 5 4 6 5–10 7–9
Pro-social score 6–10 6–10 5 5 0–4 0–4 7–10 7–10 6 6 5 5 0–4 0–4
Externalising score 0–5 0–5 6–10 6–7 11–20 8–20 0–5 0–5 6–10 6–7 11–12 8 13–20 9–20
Internalising score 0–4 0–8 5–8 9–10 9–20 11–20 0–4 0–8 5–8 9–10 9–10 11–12 11–20 13–20

As indicated in Fig 1, the prevalence of mental health total difficulties (14.0–24.5%), internalising (14.9–28.8%), emotional (10.4–25.5%), and peer relationship (17.8–25.5%) problems were higher compared to reports of previous studies. These mental health problems were more prevalent for female and male adolescents compared to other age groups in extent of percentage as explicitly visualized in Fig 1 across the three age groups. Prevalence of depression ranged from 18.0%-25.2%, reportedly higher for female adolescents aged 14–16 years.

Fig 1. Prevalence of mental health problems among school adolescents in Dire Dawa, Ethiopia.

Fig 1

3.3. Association of mental health status and socio-demographic factors

Statistical difference in prevalence was examined for each banding of subscale using the Chi-square test. The proportion of abnormal females with total difficulties, emotional and internalizing problems was significantly higher (p<0.05) than males. The prevalence of conduct and externalizing problems was highly associated with being male. The association of socio-demographic characteristics with mental health status was analyzed using Chi-square test as reported in Table 3.

Table 3. Chi-square test of mental health problems prevalence as per the original 3 band categorization (cut-off scores at 80th & 90th) between males and females.

Subscales and bandings Males (n = 366) Females (n = 365) df X2 p
n % n %
Total difficulties 2 6.913a 0.042
Normal(0–14) 307 83.9% 283 77.5%
Borderline(15–17) 29 7.9% 48 13.2%
Abnormal(18–40) 30 8.2% 34 9.3%
Emotional problems score 2 14.442a 0.001
Normal0-5) 318 86.9% 278 76.2%
Borderline = 6 23 6.3% 36 9.9%
Abnormal(7–10) 25 6.8% 51 14.0%
Conduct problems
Normal(0–3) 309 84.4% 324 88.8% 2 3.674a 0.159
Borderline = 4 30 8.2% 18 4.9%
Abnormal(5–10) 25.0 7.4% 25.0 6.3%
Hyperactivity score 2 0.488a 0.783
Normal (0–4) 329 89.9% 328 89.9%
Borderline = 5 21 5.7% 18 4.9%
Abnormal(6–10) 16 4.4% 19 5.2%
Peer problems score 2 0.930a 0.628
Normal(0–4) 298 81.4% 296 81.1%
Borderline = 5 41 11.2% 36 9.9%
Abnormal(6–10) 27 7.4% 33 9.0%
Internalising score 2 9.332a 0.009
Normal(0–8) 299 81.7% 264 72.3%
Borderline(9–10) 36 9.8% 50 13.7%
Abnormal(11–20) 31 8.5% 51 14.0%
Externalising score 2 1.896a 0.387
Normal(0–5) 272 74.3% 287 78.6%
Borderline(6–7) 50 13.7% 41 11.2%
Abnormal(8–20) 44 12.0% 37 10.1%
Pro-social score 2 0.549a 0.760
Normal(6–10) 328 89.6% 332 91.0%
Borderline = 5 18 4.9% 14 3.8%
Abnormal(0–4) 20 5.5% 19 5.2%

There was a significant difference in the prevalence of total difficulties, emotional problems and internalizing problems (Table 3). Males and females experienced similar rates of conduct problems, hyperactivity, and externalizing problems. However, males were more likely to report emotional problems (χ2 = 14.442, p = 0.001), while females were more likely to report internalizing problems (χ2 = 9.332, p = 0.009). Overall, there was a significant difference in the prevalence of total difficulties between males and females (χ2 = 6.913, p = 0.042).

A binary logistic regression model analysis showed that the odds of mental health problems were significantly associated with some socio-demographic characteristics (p<0.05); odds were different across these characteristics as reported in Table 4. The prevalence of mental health problems was significantly higher for females in upper elementary (AOR: 2.60 (0.95–7.10)) and lower secondary levels (AOR: 2.73 (1.19–6.29)) compared to upper secondary grade level (p<0.05); but it was not significantly different for males. It was twice higher among males adolescents with a self-psychoactive substance use (AOR: 2.20(1.07–4.52)) and family members experiencing psychoactive substance use (AOR:2.04(1.01–4.09)). Prevalence differences across age, maternal and paternal education, and employment status were insignificant (p>0.05).

Table 4. Association of mental health problems and socio-demographic determinants analyzed with binary logistic regression.

Prevalence of mental health problem %
Predictors Male Female
Categories UAOR(95% CI) AOR(95% CI) UAOR(95% CI) AOR(95% CI)
Age group (yrs) 11–13 Ref Ref Ref Ref
14–16 1.27(0.51–3.18) 0.959(0.25–3.7) 0.98 (0.44–2.16) 0.65 (0.20–2.06)
17–19 1.16(0.48–2.84) 0.643(0.06–6.28) 1.20 (0.55–2.64) 0.53 (0.08–3.38)
Grade level Upper elementary (5–8) 1.08(0.51–2.31) 1.44(0.50–4.15) 1.57 (0.70–3.50) 2.60 (0.95–7.10)
Lower Secondary (9–10) 1.02(0.48–2.18) 1.11(0.50–2.46) 2.22 (1.00–4.92)* 2.73 (1.19–6.29)*
Upper secondary (11–12) Ref Ref Ref Ref
Experience on psychoactive substances use
Self-experience No Ref Ref Ref Ref
Yes 0.45(0.22–0.93*  2.20(1.07–4.52)* 2.17 (0.95–4.95) 2.16 (0.95–4.92)
Any family experience No Ref Ref Ref Ref
Yes 2.01(1.01–4.00)* 2.04(1.01–4.09)* 1.07(0.63–1.84) 1.06 (0.62–1.81)
Parents practicing corporal punishment No Ref Ref Ref Ref
Yes 1.24 (0.69–2.24) 1.24 (0.69–2.23) 1.43 (0.82–2.51) 1.33 (0.75–2.36)
Adolescents report perceived worry about family problem No Ref Ref Ref Ref
Yes 1.186(0.64–2.21) 1.17(0.62–2.20) 1.24 (0.73–2.12) 1.20 (0.70–2.06)
Mother education level Non-educated Ref Ref Ref Ref
Elementary 1.31(0.50–3.43) 1.30 (0.49–3.41) 1.99 (0.57–6.96) 0.73 (0.29–1.87)
Secondary 1.30(0.66–2.57) 1.30 (0.66–2.58) 1.50 (0.34–6.70) 1.37 (0.78–2.42)
College or above 0.63(0.18–2.20) 0.64 (0.18–2.24) 2.71 (0.74–9.93) 0.52 (0.15–1.81)
Father education level Non-educated Ref Ref Ref Ref
Elementary 1.51 (0.47–4.82) 1.48 (0.46–4.74 1.03 (0.21–5.14) 1.00 (0.20–4.99)
Secondary 1.60 (0.83–3.09) 1.61 (0.83–3.11 1.04 (0.58–1.84) 1.07 (0.60–1.90)
college or above 1.42 (0.64–3.16) 1.45 (0.65–3.23 1.23 (0.61–2.46) 1.20 (0.60–2.41)
Mother job House wife/Unemployed Ref Ref Ref Ref
Work in private 0.79 (0.41–1.51) 0.79 (0.41–1.51) 1.40 (0.77–2.53) 1.40 (0.77–2.54)
Employed 0.44 (0.16–1.22) 0.44 (0.16–1.21) 0.55 (0.22–1.42) 0.55 (0.21–1.44)
Father job Unemployed/Jobless Ref Ref Ref Ref
Work in private 1.24 (0.66–2.32) 1.24 (0.66–2.33) 0.75(0.43–1.33) 0.77(0.44–1.36) 
Employed 2.56 (0.75–8.74) 2.52 (0.73–8.70) ns ns

** Significant at p<0.01

* Significant at p<0.05

However, the prevalence of mental health problems was not significantly different for males by education level. Prevalence difference was insignificant across the three age groups (11–13, 14–16, and 17–19 years), maternal and paternal education level, and types of jobs or level of employment (p>0.05). The prevalence of mental health problems was twice higher among psychoactive substance users (p<0.05) compared with non-users. Differences in prevalence existed but were insignificant across these three age groups, maternal and paternal education level, and types of jobs or level of employment (p>0.05).

3.4. Correlation of mental health literacy with total difficulty scores and well-being index

The bivariate correlations showed that the mental health literacy score was negatively associated with the total and subscale strength difficulties scores (conduct problems, emotional problems, hyperactivity-inattention, and peer problems) as it is shown in Table 5.

Table 5. Correlations among mental health variables.

Variables 1 2 3 4 5 6 7 8 9
1. SDQ Total difficulties problems score 1 -.319** -.124** .652** .700** .749** 617** .825** .863**
2. Mental wellbeing index -.319** 1 .160** -.140** -.281** -.293** -.130** -.258** -.279**
3. MHL Total mean score -.124** .160** 1 -.135** -.136** -0.006 -.088* -.166** -0.051
4. SDQ Conduct problems subscale mean score .652** -.140** -.135** 1 .345** .228** .294** .812** .319**
5. SDQ Hyperactivity problems subscale mean score .700** -.281** -.136** -.136** 1 .385** .197** .828** .380**
6. SDQ Emotional problems subscale mean score .749** -.293** -0.006 .228** .385** 1 .272** .376** .862**
7. SDQ Peer problems subscale mean score 617** -.130** -.088* .294** .197** .272** 1 .298** .721**
8. SDQ Externalizing Problems subscale mean score .825** -.258** -.166** .812** .828** .376** .298** 1 .427**
9. SDQ Internalizing problems subscale mean score .863** -.279** -0.051 .319** .380** .862** .721** .427** 1

** Correlation is significant at the 0.01 level (2-tailed)

* Correlation is significant at the 0.05 level (2-tailed)

From Table 5, the analysis found strong negative correlations between total difficulties and mental well-being, mental health literacy, and various problem behaviours. Additionally, there were moderate negative correlations between mental well-being and conduct, hyperactivity, and peer problems. Overall, the findings suggest that higher levels of total difficulties are associated with poorer mental health outcomes and increased problem behaviours.

4. Discussion

This study aimed to investigate the prevalence of mental health problems among adolescents in Dire Dawa, Ethiopia, and identify associated factors. Our findings reveal a concerning prevalence of mental health issues, with rates ranging from 15.9% to 28.8%. Internalizing problems, emotional problems, and peer relationship problems were the most common issues reported. Adolescents with personal or family histories of psychoactive substance use exhibited significantly higher rates of mental health problems. Female adolescents from upper elementary and lower secondary grades were also at increased risk. While age, parental education, and employment status did not significantly impact mental health, these results underscore the need for targeted interventions to address the mental health needs of vulnerable adolescents.

The Ethiopian government has taken several interventions to mitigate the adolescent mental health issue, establishing mental health facilities nationwide [66]. Despite the delayed initiation of the policy and lack of established systems and practices, there has been growing recognition of the importance of adolescent mental health promotion. The Ethiopian government has shown commitment to promoting mental health and addressing mental health issues in schools, for instance, by employing trained school counselors and establishing clubs in secondary schools. The government has also trained health professionals in mental health care who are better equipped to identify and treat mental health problems in adolescents—implementing psycho-education programs in schools, public awareness campaigns, and training for community leaders and media outlets for adolescents, among others [4]. The state mechanism in promoting mental health literacy in Ethiopia is that the Ministry of Health is responsible for developing and implementing mental health policies and programs and provides training for health professionals in mental health care [4]. Stakeholders including professional associations, such as the Ethiopian Mental Health Association and the Ethiopian Psychiatric Association, are involved in policy consultation, provide training and support for health professionals, and promote mental health research in Ethiopia. These policy and programs are cascaded along the government administrative levels for actual implementation. However, there is still a paucity of evidence about the mental health status of adolescents and factors that affect mental health problems and factors that contribute for effective interventions to improve adolescents’ mental health.

As a screening tool for mental health problems in children and adolescents, the SDQ is a valuable instrument [67]. However, it is important to note that the cut-off scores for the SDQ can vary across different populations [68]. In our study, we found that the cut-off scores for total difficulties and hyperactivity were slightly lower than the baseline, while the cut-off scores for internalizing were relatively higher (Table 2). These variations in cut-off scores can be attributed to cultural differences and other contextual factors [68]. Using locally derived cut-off scores ensures the cultural equivalence and applicability of the SDQ to the specific population being studied. While the SDQ is a useful screening tool, it is not a definitive diagnostic instrument [67]. If a child scores above the cut-off score, it indicates an increased risk of mental health problems but does not necessarily confirm a diagnosis. Further assessment is necessary to make a definitive diagnosis [43, 46]. These findings implied that the adolescent population in urban Ethiopia is more disadvantaged than the population on which the original cut-off scores were based. Adolescents in urban Ethiopia have been exposed to stressors like poverty, violence, or trauma. This adolescent population has less access to mental health services and is more likely to underreport mental health problems.

As shown in Fig 1, the present finding was within the same range of the Ethiopian national level prevalence of adolescent mental health problems, reportedly ranging from 17–23%, like other study results in the Ethiopian context [6971]. In our study, prevalence of total difficulties (14.0–24.5%), internalising (14.9–28.8%), emotional (10.4–25.5%), and peer relationship (17.8–25.5%) was similar that was within the range of global prevalence (10–20%) [72]. Several studies showed discrepancies in adolescent mental health problems prevalence from region to region and country to country [7376]. Similarly, these differences exist across socio-demographic characteristics [77]. From the present study, mental health problems expressed by the total strength difficulties and its subscales of problems were higher among female adolescents than male adolescents. A study among Indian children, the association between the female gender and total strength difficulties score was significant [73]. Being female was associated with emotional problems [73]. A cross-national study across 73 countries on the gender gap in adolescent mental health showed that girls have worse average mental health than boys [78]. The possible explanations include but are not limited to socio-cultural factors, gender stereotypes, trauma, and abuse that disproportionally affect girls [22, 79]. In contrast, conduct and hyperactivity/inattention problems were significantly more severe among males than females [65]. Consistent with other studies, the prevalence of conduct and externalizing problems was more significant among male adolescents than females. For example, a study in Northeast china showed a similar result [77]. A study among children and adolescents from seven European countries (Italy, Netherlands, Germany, Romania, Bulgaria, Lithuania, and Turkey) reported that externalized problems were consistently higher in males than females and reversed for internalized problems [74]. One possible explanation might be that mental health status is shaped by social, economic, and physical environments leading to inequalities that disproportionally affect gender differences and are heavily associated with risk factors for many common mental disorders [75]. According to the WHO, the relationship between the prevalence of mental health problems and poverty indices was statistically significant [76]. These poverty indices are education disparity, low income, a lack of material goods, job, and housing obstacles. For several cultural and traditional reasons, these factors impact females more than boys [76].

Odds of mental health problems were significantly associated with some socio-demographic characteristics (p<0.05) differing in magnitude across these characteristics. In this study, the prevalence of mental health problems was significantly higher for females in upper elementary and lower secondary levels than for upper secondary grade levels (p<0.05), consistent with reports of several studies [75, 76]. According to WHO report, educational status is one of the major factors determining adolescent mental health outcomes [76]. However, the difference was insignificant for male adolescents in this study. Furthermore, differences in prevalence have existed but little across the three age groups(early, middle and late adolescents) maternal and paternal education level, and job types or level of employment (p>0.05). The present study’s prevalence of mental health problems was twice high among adolescents with a self and/or family members’ experience of psychoactive substance use (p<0.05). On the contrary, a study in Northeast China showed that the prevalence of any mental disorders and internalizing disorders was significantly lower in younger adolescents than in elders. Children aged 11–14 years had the highest prevalence of internalizing disorders [77]. It was also inconsistent with a study in developing countries showing that lower maternal education was significantly associated with abnormal total SDQ scores [31].

The present study revealed mental health literacy was negatively correlated with strength difficulties scores and positively correlated with mental well-being; both were significantly correlated but weaker in magnitude. These findings were consistent with existing theories and the results of previous studies. For instance, a study demonstrated that an inadequate level of mental health literacy was negatively associated with depression [39]. The prevalence of depression was 1.52 times higher in those with levels of inadequate MHL than in those who demonstrated an adequate level of MHL [39]. Another study depicted MHL as an explanatory variable of the mental well-being of adolescents, which has a positive correlation with it [80]. A possible explanation for the negative association between mental health literacy and strength difficulties scores might be that low mental health literacy contributes to the mental health promotion and prevention gap [31, 34, 81, 82]. Low mental health literacy exacerbates barriers and difficulties in accessing treatment for mental health problems [24, 83].

Mental health literacy significantly influences adolescents’ perceptions and emotional responses [80], reflecting mental health status and subjective mental well-being. Several studies revealed that mental health literacy had a significant relationship with mental health status [39, 84, 85]. A higher level of mental well-being has been reported among adolescents with better know-how about obtaining mental health services [80]. Adolescents’ awareness of symptoms, causes, and mental illness treatment contributes to favorable attitudes toward seeking help [15]. Similarly, adolescents with better mental health literacy are less likely to engage in problematic health behaviours and have better help-seeking intention and self-efficacy, contributing to a better mental health and well-being [86]. Mental health literacy is about the information, attitudes, and awareness of mental health concerns that improve self-efficacy, help-seeking intention, and health behaviour, influencing long-term health outcomes and quality of life. A lack of understanding of the symptoms and nature of mental health disorders and alternate sources of support could explain teenagers’ low help-seeking intention and behaviour [15]. Of course, help-seeking intention and self-efficacy may reflect only one of several mechanisms. Better mental health literacy leads to better mental well-being. Higher help-seeking intention and self-efficacy would only partially mediate the relation between higher mental health literacy and better mental well-being. Components of health behavior expressed in actions, targets, contexts, and time are the most determining factors of mental health outcomes [87, 88].

Mental health literacy influences mental health services and help-seeking for treatment [89]. Hence, mental health literacy is essential to improve but not always corresponds to help-seeking behaviours [90]. Jorm and his colleagues revealed that changing knowledge of mental health in principle is vital; however, changing heartily emotional reactions to practice caring and preventing mental disorders may be much more challenging [10]. Help-seeking, interchangeably health-seeking, has become one of the essential perspectives in understanding causes and factors for patient delay from appropriate action across different health conditions [91]. Despite the prevalent mental health problems and poor well-being, adolescents’ unwillingness and low intention to seek help usually result in delays in timely treatment [32]. Most adolescents with mental health problems are reluctant and miss the use of healthcare for mental health, which increases the complexity of social, mental, and general health outcomes [92]. The findings from this study implied that promoting mental health literacy can improve subjective mental well-being [80].

The recently revised policy released by The Ethiopian Ministry of Health in 2017 aimed to improve adolescents’ mental health by providing early identification, prevention, and treatment services [4, 21]. Following the policy, programs were launched in 2018, including school-based mental health programs, community-based mental health services, and training for health care providers [21]. Empirical evidence on early identification of vulnerable groups, individuals reporting symptoms of mental health difficulties and the associated actors could enhance the impact and effectiveness of these programs implementation [4, 21]. In this regard, demographic, socioeconomic and cultural appropriate approaches should be applied to mental health policies for mental health promotion and mental illness prevention.

5. Limitations

The study has some inherent limitations. It is not applicable to generalize these findings across the country; because Ethiopia exhibits multicultural and multiethnic diversity and multiple socio-demographic backgrounds. It could not even be generalized to all adolescents of the study area, because the samples were selected from the age group (11–19) and grade level (5–12), adolescents at the age of 10 years and lower grade levels were excluded during the first cycle of elementary schools during school sampling. The present study is conducted on the urban adolescents and did not address rural adolescents. The study was quantitative and lacked the qualitative aspect of how and why these findings were observed.

6. Conclusion

This study found a concerning prevalence of mental health problems among adolescents in Dire Dawa, Ethiopia, aligning with global estimates. These problems included total difficulties, internalizing problems, emotional problems, and peer relationship problems. Adolescents with personal or family histories of substance use were at significantly higher risk. Females and younger adolescents were also more likely to experience mental health issues. Self-psychoactive substance uses and family members experiencing psychoactive substance use were associated with increased mental health difficulties. Female adolescents were more likely to experience mental health problems than males, as indicated by higher scores on total difficulties and its subscales. This aligns with previous research.

Mental health literacy is negatively correlated with total difficulties and positively associated with mental well-being and the study highlights the importance of improving mental health literacy among adolescents in Dire Dawa. These findings support existing theories and suggest that promoting mental health literacy can improve adolescent mental health. Prioritizing vulnerable groups and individuals experiencing mental health difficulties is crucial. This can be achieved through targeted interventions that consider gender, age, family background, and other socio-demographic factors. Future research should explore these factors in more depth using qualitative methods and should explore additional factors influencing mental health. Future studies with larger sample sizes should conduct multivariable analyses to further explore the complex relationships between mental health literacy, well-being, and mental health problems while controlling for potential confounding factors.

Supporting information

S1 Data

(SAV)

pone.0295545.s001.sav (166KB, sav)

Acknowledgments

This study is a part of doctoral thesis of the first author Hailemariam Mamo Hassen under the supervision of Prof. Manas Ranjan Behera at the School of Public Health, Kalinga Institute of Industrial Technology (KIIT) University, Bhubaneswar, India. The authors would like to thank the survey respondents for their participation and contributions to the study.

Data Availability

All relevant data are within the paper and its Supporting Information files.

Funding Statement

The authors received no specific funding for this work.

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Decision Letter 0

I Marion Sumari-de Boer

16 Aug 2023

PONE-D-23-13300Mental Health Issues and the Association of Mental Health Literacy among Adolescents in Urban EthiopiaPLOS ONE

Dear Dr. Hassen,

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Reviewer #1: Yes

Reviewer #2: Yes

********** 

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Reviewer #1: Yes

Reviewer #2: Yes

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********** 

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Reviewer #1: The article is quite an important work which can be a value addition to the literature on mental health especially in Ethiopian region. However, the article needs minor revision before being accepted for the publication. The comments are as below,

1) The precise location of the focus of the study is better to be mentioned in the abstract to main transparent claims and ground of study.

2) The article needs justification of the choice of themes and methods used. For example, it is always better to connect adolescents'' mental health with life span development and justify the argument in such line of thought. Similarly, more justification is needed in choice of SDQ, WHO-5 to strengthen the method section.

3) In discussion section, the claim "the cut-off score ... for internalizing scores" needs expanded rationalisation and justification to make it more relevant for the purpose of the article.

4) Page 8, third paragraph last sentence - " A cross sectional study across 73 countries..."; p.11 conclusion statement "Female adolescents ..." need strengthened rationalisation for what it implies for this study.

5) More focus is needed in following the prescribed reference style accurately and consistently, both for in text citation (P.10) and reference list (Ref 4,5, 12,16).

Overall, its a good work to be accepted for publication with these minor revisions.

Reviewer #2: The introduction section provides an exhaustive literature review on mental health issues. When explaining a scenario, start with the global scenario followed by Africa, Ethiopia, and then the situation of mental health literacy in the study area.

What is the government intervention to mitigate the issue? What are the state mechanisms promoting mental health literacy in Ethiopia? The author can discuss these interventions in discussion sections.

The author should discuss their policy and programme related to mental health for a more comprehensive understanding.

The author should highlight the key inference of the present study, how this study enhances the knowledge of mental health literacy among young adolescents in Ethiopia.

Suggest a few major findings, how the demographic and socioeconomic factors are leading in addressing the current mental health literacy issues in Ethiopia. Is it applicable across Ethiopia, irrespective of all ethnic groups?

********** 

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Reviewer #1: Yes: Rhyddhi Chakraborty Ph.D., FHEA, FRSPH

Reviewer #2: No

**********

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PLoS One. 2024 Oct 24;19(10):e0295545. doi: 10.1371/journal.pone.0295545.r002

Author response to Decision Letter 0


9 Nov 2023

Response to Reviewers

Title: Mental health issues and the association of mental health literacy among adolescents in urban Ethiopia (PONE-D-23-13300)

Dear Editor,

We thank you for your and the reviewers' constructive feedback and the opportunity to revise and resubmit our manuscript. We carefully considered the comments, and the manuscript was revised. We appreciate and thank you very much for your feedback on the suggestion. We followed PLOS ONE's style requirements and moved the ethics statement into the Methods section of the manuscript. We referred to Figure 1 and the tables in the text as part of the main manuscript. We reviewed the reference list to ensure it is complete and correct to check for errors. We have addressed the feedback accordingly.

Three separate papers are submitted to the system: one has a marked-up copy of the manuscript that highlights changes with track changes, an unmarked version of the revised paper without tracked changes, and a rebuttal letter for each point raised by the academic Editor and reviewers. We are confident that the updated version is appropriate for publishing and anticipate hearing from you soon.

With regards,

Hailemariam Mamo Hassen (PhD)

On behalf of the authors.

Point-by-point response for Reviewers' comments

Dear reviewers, we are grateful for the feedback and constructive comments helpful for improving the manuscript quality.

Reviewer #1 Comments

Reviewer comment: The article is quite an important work that can be a valuable addition to the literature on mental health, especially in the Ethiopian region. However, the article needs minor revision before being accepted for publication. The comments are addressed below.

Author's response: Thank you. We appreciate your constructive comments and agree on that, and the comments are addressed below.

Reviewer comment: The precise location of the focus of the study is better mentioned in the abstract to maintain transparent claims and ground of study.

Author's response: Thank you very much, dear reviewer. We mentioned the precise location of the focus of the study in the abstract on page 2, line #1, that the study was conducted in Dire Dawa City, Eastern Ethiopia. The details are also already presented in the main body of the paper.

Reviewer comment: The article needs justification for the themes and methods used. For example, it is always better to connect adolescents'' mental health with life span development and justify the argument in such a line of thought.

Authors' response: Thank you for your comment. We have added more justifications for the choice of themes and methods used to connect adolescents" mental health with life span development. You may kindly refer to the revised manuscript (Page 4)

Reviewer comment: Similarly, more justification is needed in the choice of SDQ and WHO-5 to strengthen the method section.

Authors' response: Once again, we appreciate your concern. We justified the choice of SDQ, WHO-5, for the measurement of mental health status in the method section. You may kindly refer to the revised manuscript (Page 5)

Reviewer comment: In the discussion section, the claim "the cut-off score ... for internalizing scores" needs expanded rationalization and justification to make it more relevant to the article's purpose.

Authors' response: Thank you, dear reviewer. We explained the claim and rationalization/justification on "the cut-off score ... for internalizing scores" and other subscales in the discussion section; you may kindly refer to the revised manuscript (Page 23)

Reviewer comment: Page 8, third paragraph last sentence - "A cross-sectional study across 73 countries..." p.11 conclusion statement "Female adolescents ..." need to strengthen rationalization for what it implies for this study.

Authors' response: Thank you so much for your important concern. We Strengthened rationalization for what it implies for this study for the sentences on:

• On the revised manuscript, page 24, fourth paragraph - "A cross-sectional study across 73 countries..."(comment incorporated on page line in the revised version. You may kindly refer to the revised manuscript (Page 24)

• On the revised manuscript page 29, second paragraph conclusion statement You may kindly refer to the revised manuscript (Page 29)

Reviewer comment: More focus is needed on following the prescribed reference style accurately and consistently for in-text citation (P.10) and reference lists (Ref 4,5, 12,16).

Authors' response: We appreciate your concern. We checked and revised all the references, including these commented references, as per the PLOS ONE reference style for its accuracy and consistency, including the commented references in-text citation (P.10) and reference list (Ref 4,5, 12,16)

Reviewer comment: Overall, it is a good work to be accepted for publication with these minor revisions.

Authors' response: Thank you very much.

Reviewer #2 Comments:

Authors' response to Reviewer #2 Comments:

Dear reviewer #2, we acknowledge all insightful comments and fully agree with the suggestions. We addressed the comments one by one.

Reviewer comment: The introduction provides an exhaustive literature review on mental health issues. When explaining a scenario, start with the global scenario followed by Africa, Ethiopia, and mental health literacy in the study area.

Authors' response: Thank you very much, dear reviewer. We added more explanations, starting with the global scenario followed by Africa, Ethiopia, and mental health literacy in the study area. You may kindly refer to the revised manuscript (Introduction Page 3, first paragraph)

Reviewer comment: What is the government intervention to mitigate the issue? What are the state mechanisms promoting mental health literacy in Ethiopia? The author can discuss these interventions in discussion sections.

Authors' response: Thank you so much for your essential concern. We discussed the government intervention to mitigate the issue, state mechanisms promoting mental health literacy in Ethiopia, and their policy and programme related to mental health for a more comprehensive understanding in the discussion sections with additional references to the national health policy and programme. You may kindly refer to the revised manuscript ( throughout the discussion and mainly in the first paragraph of the discussion part, Page 22)

Reviewer comment: The author should discuss their policy and programme related to mental health for a more comprehensive understanding.

Authors' response: We appreciate your crucial concern. We discuss the policy and programme related to mental health in Ethiopia throughout the manuscript for a more comprehensive understanding and, most importantly, discussion in the last paragraph of the discussion. (Pages 27-28)

Reviewer comment: The author should highlight the key inference of the present study, how this study enhances the knowledge of mental health literacy among young adolescents in Ethiopia.

Authors' response: Thank you so much. We revised and highlighted the key inference of the study, noting the limitations of generalization in the limitation and conclusion parts (pages 28&29).

Reviewer comment: Suggest a few major findings, how the demographic and socioeconomic factors are leading in addressing the current mental health literacy issues in Ethiopia.

Authors' response: Thank you, dear reviewer. We revised the manuscript, presenting the significant findings and how the demographic and socioeconomic factors imply addressing the current mental health literacy (Page 29 paragraph 2)

Reviewer comment: Is it applicable across Ethiopia, irrespective of all ethnic groups?

Authors' response: We appreciate your crucial concern. As it is presented in the limitation section, It is not applicable to generalize these findings across the country because Ethiopia exhibits multicultural and multiethnic diversity and multiple socio-demographic backgrounds. It could not even be generalized to all adolescents of the study area. (Page 28, limitation, paragraph 1)

Attachment

Submitted filename: Response to Reviewers.docx

pone.0295545.s002.docx (50.2KB, docx)

Decision Letter 1

Tesera Bitew

25 Jan 2024

PONE-D-23-13300R1Mental health issues and the association of mental health literacy among adolescents in urban EthiopiaPLOS ONE

Dear Dr. Hassen,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

Please submit your revised manuscript by Mar 10 2024 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

  • A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.

  • A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.

  • An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols.

We look forward to receiving your revised manuscript.

Kind regards,

Marianne Clemence, Staff Editor, on behalf of

Tesera Bitew, PhD

Academic Editor

PLOS ONE

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Ethical requirements - please note that if you do not address these requests your manuscript may be rejected

1) You indicated that you had ethical approval for your study. In your Methods section, please ensure you have also stated whether you obtained consent from parents or guardians of the minors included in the study or whether the research ethics committee or IRB specifically waived the need for their consent.

2) We note that your study was approved by both the ethics committees of Haramaya University and KIIT University, but you have only provided a copy of the approval received from Haramaya University. Please upload a copy (file type Other) of the original ethics approval letter received from KIIT University, as required by question 1 of the human subject research checklist. If the original letter is not in English, please also provide an English translated version in the supporting file. 

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Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice.

Additional Editor Comments:

Dear author,

It is my pleasure that your manuscript has been accepted once you accomodate comments raised by the two reviewers.

reviewer 1

reviewer 2:

Would you please review your claims on the discussion section regarding government actions taken at school level with regard to mental health promotion and prevention as there are no promising activities? These are actually policy promises than actual practices.

I think you better consider including the predictor variables in the method part.

Your sampling strategy should discuss the clusters selected all the stages precisely.

The statement on page 13 that begins with "These mental health problems were..." does not provide a clear comparison.

Would you please mention any bases for your age categorization and its subsequent implication for mental health promotion and prevention?

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Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #2: All comments have been addressed

Reviewer #3: (No Response)

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2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #2: Yes

Reviewer #3: Partly

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #2: Yes

Reviewer #3: Yes

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4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #2: Yes

Reviewer #3: Yes

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5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #2: Yes

Reviewer #3: Yes

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6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #2: Author has addressed all the comments and suggestions. Mental health literacy is an emerging issues which demand more attention for overall health and well-being.

Reviewer #3: Would you please review your claims on the discussion section regarding government actions taken at school level with regard to mental health promotion and prevention as there are no promising activities? These are actually policy promises than actual practices.

I think you better consider including the predictor variables in the method part.

Your sampling strategy should discuss the clusters selected all the stages precisely.

The statement on page 13 that begins with "These mental health problems were..." does not provide a clear comparison.

Would you please mention any bases for your age categorization and its subsequent implication for mental health promotion and prevention?

**********

7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #2: No

Reviewer #3: No

**********

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.

PLoS One. 2024 Oct 24;19(10):e0295545. doi: 10.1371/journal.pone.0295545.r004

Author response to Decision Letter 1


12 Feb 2024

Response to Reviewers

Title: Mental health issues and the association of mental health literacy among adolescents in urban Ethiopia (PONE-D-23-13300)

Dear Editor,

We thank you for your and the reviewers' constructive feedback and the opportunity to revise and resubmit our manuscript. We carefully considered each point raised by the academic editor and reviewers and revised the manuscript. We appreciate and thank you very much for the feedbacks and comments. We followed PLOS ONE's style requirements.

Point raised by the academic editor were regarding whether consent obtained from parents or guardians of the minors, ethics approval letter from two institutions of which one was missing and discrepancy in date difference for secretary and chair person for ethics approval letter obtained from Haramaya University and concern to ensure completeness and correctness of references.

Dear Academic editor, regarding consent from parents or guardians of the minors, written informed consent was obtained from parents of adolescents aged under fifteen years had offered their consent and adolescents of fifteen and above years were factored out following the school counsellors and school principals adequate explanation about their level of maturity and decisional capacity ((page 10) with due reference of the guideline International Ethical Guidelines for Health-related Research Involving Humans: Prepared by the Council for International Organizations of Medical Sciences (CIOMS) in collaboration with the World Health Organization (WHO,2016). However, respective school principals as a duly authorized representative had expressed their consent both orally and signed on consent forms for all participants.

Regarding the ethics approval letters, ethics approval letter from the two institutions (KIIT University and Haramaya University) are merged and attached in this revised submission. The discrepancy of the date of signature from the Chairperson (dated 11/02/2018) and Secretary (dated 11/02/2020) on same document was confirmed as typo while the typist was writing and the letter issued unnoticed. We understand that it requires a correction. However, our application for correction from the Institutional review board of Haramaya University failed because the Institutional review board has restructured and the Signers were changed by other individuals. We sincerely request your esteemed editor to understand that this discrepancy is typo while the typist was writing and we kindly request you recognize this issue.

We reviewed the reference lists to ensure it is complete and correct.

Dear editor, we appreciate the comments raised by the reviewers and we accommodate each comment one by one in the manuscript indicated by track change.

Three separate papers are submitted to the system: one has a marked-up copy of the manuscript that highlights changes with track changes, an unmarked version of the revised paper without tracked changes, and a rebuttal letter for each point raised by the academic Editor and reviewers. We are confident that the updated version is appropriate for publishing and anticipate hearing from you soon.

With regards,

Hailemariam Mamo Hassen (PhD), (First and corresponding author)

On behalf of the authors.

Point-by-point response for Reviewers' comments

Dear reviewers, we are grateful for the feedback and constructive comments helpful for improving the manuscript quality.

Reviewer #2 Comments

Thank you very much, dear reviewers.

Reviewer #2 commented that we authors have addressed all the comments and suggestions stating that mental health literacy is an emerging issue which demand more attention for overall health and well-being.

Authors' response Thank you very much:

Reviewer #3 Comments

Author's response: Thank you. We appreciate your constructive comments and agree on the comments and addressed accordingly. .

Reviewer #3 comment: Would you please review your claims on the discussion section regarding government actions taken at school level with regard to mental health promotion and prevention as there are no promising activities? These are actually policy promises than actual practices.

Authors' response: Dear Reviewer, thank you so much for your essential concern. We agree that the government actions taken at school level with regard to mental health promotion and prevention are policy promises than actual practices. Accordingly, we discussed these points. Despite the delayed initiation of the policy and lack of established systems and practices, there has been growing recognition of the importance of adolescent mental health promotion. The Ethiopian government has shown commitment to promoting mental health and addressing mental health issues in schools, for instance, by employing trained school counselors and establishing clubs in schools in secondary schools. (stated on page 25)

Reviewer #3 comment: I think you better consider including the predictor variables in the method part.

Author's response: Thank you very much, dear reviewer. We included the predictor variables briefly in the method part (page 8). “The predictor variables mainly focusing on age, grade level, self or any family member experience with psychoactive substance use, parents practicing corporal punishment, perceived worry about family problems, parents education, and job status were collected by using questionnaires.”

Reviewer #3 comment: Your sampling strategy should discuss the clusters selected all the stages precisely.

Author's response: Thank you. We mentioned the sampling strategy briefly in the method part (page 8). “A combination of multistage (schools, classrooms, then individual students) and systematic and random (using the list of the students in fixed intervals of their roll numbers) was used to select study participants from public and private schools.”

Reviewer #3 comment: The statement on page 13 that begins with "These mental health problems were..." does not provide a clear comparison.

Author's response: Once again, we appreciate your concern. We have compared and indicated in the figure 1 in the revised manuscript, page 14. We stated that “These mental health problems were more prevalent for female and male adolescents compared to other age groups in extent of percentage as explicitly visualized in Figure 1 across the three age groups. Prevalence of depression ranged from 18.0%-25.5%, reportedly higher for female adolescents aged 14-16 years ( page 14).

Reviewer #3 comment: Would you please mention any bases for your age categorization and its subsequent implication for mental health promotion and prevention?

Author's response: Thank you very much, dear reviewer. We already mentioned the bases for your age categorization and its subsequent implication on page 11 of the last 4 lines #6-9; “The age range for adolescents and grouping was based on UNICEF adolescents' age categorization as early, middle, and late adolescence age groups, which is helpful to target mental health promotion and prevention efforts during these stages to address their respective mental health demands.”

Attachment

Submitted filename: Response to Reviewers.docx

pone.0295545.s003.docx (50.4KB, docx)

Decision Letter 2

Yared Reta Abayneh

27 Aug 2024

PONE-D-23-13300R2Mental health issues and the association of mental health literacy among adolescents in urban EthiopiaPLOS ONE

Dear Dr. Hailemariam,

Thank you for submitting your manuscript to PLOS ONE. After careful consideration, we feel that it has merit but does not fully meet PLOS ONE’s publication criteria as it currently stands. Therefore, we invite you to submit a revised version of the manuscript that addresses the points raised during the review process.

Please submit your revised manuscript by Oct 11 2024 11:59PM. If you will need more time than this to complete your revisions, please reply to this message or contact the journal office at plosone@plos.org. When you're ready to submit your revision, log on to https://www.editorialmanager.com/pone/ and select the 'Submissions Needing Revision' folder to locate your manuscript file.

Please include the following items when submitting your revised manuscript:

  • A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'.

  • A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'.

  • An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'.

If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: https://journals.plos.org/plosone/s/submission-guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at https://plos.org/protocols?utm_medium=editorial-email&utm_source=authorletters&utm_campaign=protocols.

We look forward to receiving your revised manuscript.

Kind regards,

Yared Reta Abayneh, MSC in ICCMH

Academic Editor

PLOS ONE

Journal Requirements:

Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice.

Additional Editor Comments:

Dear Dr. Hailemariam,

I hope you are well. I’m writing regarding your manuscript titled “Mental health issues and the association of mental health literacy among adolescents in urban Ethiopia.” I apologize for the delay in the review process, which was due to difficulties in securing reviewers. We appreciate your patience during this time.

We were able to involve multiple reviewers, whose diverse feedback will strengthen the quality of your manuscript. Based on their comments, we request that you make some minor revisions. Please respond to each point raised in the attached reviews and indicate the changes made in your revised manuscript.

Thank you for your cooperation and understanding. We look forward to receiving your revised submission.

[Note: HTML markup is below. Please do not edit.]

Reviewers' comments:

Reviewer's Responses to Questions

Comments to the Author

1. If the authors have adequately addressed your comments raised in a previous round of review and you feel that this manuscript is now acceptable for publication, you may indicate that here to bypass the “Comments to the Author” section, enter your conflict of interest statement in the “Confidential to Editor” section, and submit your "Accept" recommendation.

Reviewer #2: All comments have been addressed

Reviewer #4: All comments have been addressed

Reviewer #5: (No Response)

Reviewer #6: (No Response)

**********

2. Is the manuscript technically sound, and do the data support the conclusions?

The manuscript must describe a technically sound piece of scientific research with data that supports the conclusions. Experiments must have been conducted rigorously, with appropriate controls, replication, and sample sizes. The conclusions must be drawn appropriately based on the data presented.

Reviewer #2: Yes

Reviewer #4: Partly

Reviewer #5: No

Reviewer #6: Yes

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3. Has the statistical analysis been performed appropriately and rigorously?

Reviewer #2: Yes

Reviewer #4: Yes

Reviewer #5: No

Reviewer #6: Yes

**********

4. Have the authors made all data underlying the findings in their manuscript fully available?

The PLOS Data policy requires authors to make all data underlying the findings described in their manuscript fully available without restriction, with rare exception (please refer to the Data Availability Statement in the manuscript PDF file). The data should be provided as part of the manuscript or its supporting information, or deposited to a public repository. For example, in addition to summary statistics, the data points behind means, medians and variance measures should be available. If there are restrictions on publicly sharing data—e.g. participant privacy or use of data from a third party—those must be specified.

Reviewer #2: Yes

Reviewer #4: Yes

Reviewer #5: (No Response)

Reviewer #6: Yes

**********

5. Is the manuscript presented in an intelligible fashion and written in standard English?

PLOS ONE does not copyedit accepted manuscripts, so the language in submitted articles must be clear, correct, and unambiguous. Any typographical or grammatical errors should be corrected at revision, so please note any specific errors here.

Reviewer #2: Yes

Reviewer #4: Yes

Reviewer #5: No

Reviewer #6: Yes

**********

6. Review Comments to the Author

Please use the space provided to explain your answers to the questions above. You may also include additional comments for the author, including concerns about dual publication, research ethics, or publication ethics. (Please upload your review as an attachment if it exceeds 20,000 characters)

Reviewer #2: All comments have been address. The literature review is meticulously organised, establishing a strong basis for the research. The technique is thoroughly clarified, ensuring clarity and the capacity to replicate the study. The study is rigorously supported by suitable statistical methodologies, and the findings are clearly presented and explained.

All the best!

Reviewer #4: Thank you author(s) for your valuable research. Because mental health concerns is crucial for policy makers & any concerned bodies of the intended areas especially regarding adolescents. My concerns in general is that; you indicated that the policy makers in the area were you did your research more or less on striving to strengthen the strategy to tackle mental health problems. Thus it is not your concern to mention it in detailed.

Reviewer #5: The authors have undertaken important work and the conclusions could make far reaching contributions to policy. However, I do not believe that adequate rigour has been applied in the analysis and write-up, and the manuscript needs to be edited for grammar and readability. The specific comments will be found in the attached copy of the manuscript. Please find a few key points below:

-Please be specific where you can be. Words like "about" when talking about your own data suggest that you are not sure of the data you are presenting.

- Avoid extraneous details in the discussion. There was too much written about the study tool in the discussion that should be cut or moved to the methods section

- It is curious that a multivariable analysis was not done to test the independence of the observed association between mental health literacy and wellbeing and mental health problems, when several variables that were in your dataset (like age and proxies for socioeconomic status) could easily be confounders. I strongly recommend performing this analysis.

- I recommend that the authors seek independent editing of the manuscript.

Reviewer #6: Thank you for the opportunity to review this work. The manuscript titled under review present important evidence for adolescent mental health in Africa and by extension low-middle income countries. It applied sound analytical approaches to answer the object of the study. However, the manuscript requires major revisions before being accepted for publications.

Kindly find attached my review comments.

Introduction

- Page 5 paragraph 3: The description and justification of the SDQ and WHO wellbeing 5 should be included in the methods section when discussing the instruments used.

- Page 7: Study objective 3 “to examine the impact of socio-demographic characteristics on mental health issues” should be revised as the cross-sectional nature of the study does not allow for cause-and-effect relationships to be established. Also, the analytical framework used could only examine the association between socio-demographic characteristics and health issues.

- Consider revising the introduction, be succinct and thoughts should follow in a logical sequence.

Results

It will be helpful to present a table on the sociodemographic characteristics of the participants before presenting other results. This should indicate the frequencies, percentage, and confidence intervals.

- Page 11 - Table 1 should added to supplementary tables or removed from the manuscript.

- Page 13- the prevalence estimates as stated in the manuscript does not correspond with results in fig 1. E.g. Prevalence of total difficulties ranged from 14.0%-24.5% not “15.9-25.5%”, internalizing 14.9-28.8% not “14.8-28.4%” Please check and revise all the results in the manuscript.

- Report the results in table 2 in the manuscript. Provide a description beneath the table for “a” as denoted in the table.

- “It was twice higher among adolescents with a self and family members experiencing psychoactive substance use (p0.05)” … state the AOR and CI’s.

- Table 3: Use Ref instead of “1” to indicate the reference group in present the results for the logistic regression

- Present the results for table 4 correlational analysis in the manuscript.

The table format is a bit cumbersome. I suggest you review your tables and present them in APA format if not otherwise indicated.

Discussion

While the authors have provided sufficient references to support the findings of the study, the presentation appears not well structured making it difficult to follow.

- Consider beginning your discussion by first providing a summary of your key findings based on the objectives for the study. Then you can proceed to discuss them one after the other in an organized and precise manner.

Conclusions

The conclusion appears a bit elaborate. Please summarize the key objective and key findings and possible recommendation in a precise manner.

Minor revisions

- Page 30 paragraph 3 Kindly revise in-text citation. “Anthony F. Jorm and his colleagues” should read Jorm and his colleagues.

- Kindly review the entire manuscript to ensure that all in-text citations are properly cited.

- The authors should revise the manuscript to improve the flow and readability of the text.

**********

7. PLOS authors have the option to publish the peer review history of their article (what does this mean?). If published, this will include your full peer review and any attached files.

If you choose “no”, your identity will remain anonymous but your review may still be made public.

Do you want your identity to be public for this peer review? For information about this choice, including consent withdrawal, please see our Privacy Policy.

Reviewer #2: No

Reviewer #4: No

Reviewer #5: Yes: John-Paul Omuojine, MBChB FWACP(Psych)

Reviewer #6: No

**********

[NOTE: If reviewer comments were submitted as an attachment file, they will be attached to this email and accessible via the submission site. Please log into your account, locate the manuscript record, and check for the action link "View Attachments". If this link does not appear, there are no attachment files.]

While revising your submission, please upload your figure files to the Preflight Analysis and Conversion Engine (PACE) digital diagnostic tool, https://pacev2.apexcovantage.com/. PACE helps ensure that figures meet PLOS requirements. To use PACE, you must first register as a user. Registration is free. Then, login and navigate to the UPLOAD tab, where you will find detailed instructions on how to use the tool. If you encounter any issues or have any questions when using PACE, please email PLOS at figures@plos.org. Please note that Supporting Information files do not need this step.

Attachment

Submitted filename: PONE-D-23-13300_R2.pdf

pone.0295545.s004.pdf (5.7MB, pdf)
PLoS One. 2024 Oct 24;19(10):e0295545. doi: 10.1371/journal.pone.0295545.r006

Author response to Decision Letter 2


25 Sep 2024

A rebuttal letter

Dear Editor and Reviewers,

Thank you for your valuable feedback on our manuscript “Mental health issues and the association of mental health literacy among adolescents in urban Ethiopia (PONE-D-23-13300)”. We are pleased to learn that all reviewers are satisfied with the responses provided to their initial comments. We believe the revised manuscript now fully meets PLOS ONE's publication criteria. For the current version the manuscript, we have carefully considered all of the comments and have made required revisions to address your concerns. All comments have been addressed one by one. The comments raised by the editor and reviewers and authors responses are presented in tabular form for easy reference on the comments and responses. The A marked-up copy of the manuscript with Track Changes is attached for your review.

We believe that the revised manuscript now addresses all of the reviewers' comments and is suitable for publication in PLOS ONE. Thank you again for your time and consideration.

Sincerely,

Hailemariam Mamo Hassen(Ph.D)

Corresponding author

Comments by the editor and reviewers and Authors response

Comments Authors responses

Editor comment

Please review your reference list to ensure that it is complete and correct. If you have cited papers that have been retracted, please include the rationale for doing so in the manuscript text, or remove these references and replace them with relevant current references. Any changes to the reference list should be mentioned in the rebuttal letter that accompanies your revised manuscript. If you need to cite a retracted article, indicate the article’s retracted status in the References list and also include a citation and full reference for the retraction notice. Thank you for your careful review of our manuscript.

We have thoroughly reviewed our reference list to ensure its completeness and accuracy. There are no any retracted references papers.

We request that you make some minor revisions. Please respond to each point raised in the attached reviews and indicate the changes made in your revised manuscript. Thank you for your prompt review of our manuscript. We appreciate the thoughtful comments from the editor and the reviewers and have carefully considered each point raised incorporated the suggested revisions into the revised manuscript attached. Please find below a detailed response to each of the reviewer's comments:

Reviewers Comments

Reviewer #2 Comments: All comments have been addressed. The literature review is meticulously organized, establishing a strong basis for the research. The technique is thoroughly clarified, ensuring clarity and the capacity to replicate the study. The study is rigorously supported by suitable statistical methodologies, and the findings are clearly presented and explained.

All the best! We would like to express our sincere gratitude. Thank you for your valuable feedback.

Reviewer #4 Comments: Thank you author(s) for your valuable research. Because mental health concerns is crucial for policy makers & any concerned bodies of the intended areas especially regarding adolescents.

My concern in general is that; you indicated that the policy makers in the area were you did your research more or less on striving to strengthen the strategy to tackle mental health problems. Thus it is not your concern to mention it in detailed. Thank you for your thoughtful comments and appreciation of our research. We acknowledge that mental health concerns are indeed critical for policymakers and relevant stakeholders, particularly among adolescents.

We understand your concern regarding the level of detail provided on the policy makers' efforts to strengthen mental health strategies.

We believe that it's important to acknowledge the broader context within which our research is situated. Statements on policy makers and strategies were mentioned regarding a paucity of evidence about the increasing demand for adolescents’ mental health and well-being outcome measures to inform the public and policymakers and professionals involved in policy consultation, and how our study contribute evidences mentioning the delayed initiation of the policy and lack of established systems and practices despite government growing recognition and commitment to promoting mental health. Additionally, we mentioned the existing recently drafted policy released by The Ethiopian Ministry of Health in 2017 aimed to improve adolescents' mental health by providing early identification, prevention, and treatment services. [4,21] and programs launched in 2018, including school-based mental health programs, community-based mental health services, and training for health care providers.[21]

Therefore, we kindly note that presence of the evidence statement would be essential.

Thank you.

Reviewer #5 Comments:

The authors have undertaken important work and the conclusions could make far reaching contributions to policy. However, I do not believe that adequate rigour has been applied in the analysis and write-up, and the manuscript needs to be edited for grammar and readability. The specific comments will be found in the attached copy of the manuscript. Please find a few key points below: Thank you for your valuable feedback. We have carefully addressed your specific comments and made significant improvements to our manuscript. We've strengthened our methodology, clarified our writing, and refined our conclusions to better reflect our findings and the policy implications. We believe these revisions have enhanced the quality of our work and hope it meets your journal's high standards.

Hence, please find below the detailed responses to each of the comments (a-d).

a. Reviewer #5 Comments: Please be specific where you can be. Words like "about" when talking about your own data suggest that you are not sure of the data you are presenting. Thank you for your careful review of our manuscript. We appreciate your attention to detail and your suggestion to replace the word "about" where appropriate. We have carefully reviewed our manuscript and have made the necessary changes to provide more precise and accurate information.

We have replaced "about" with specific terms where appropriate (page 2 line27), ensuring that our data is presented clearly and accurately. Additionally, we have provided exact numbers or percentages whenever possible to enhance the precision of our reporting.

We believe that these revisions have strengthened the clarity and accuracy of our manuscript and have addressed your concerns effectively. Thank you again for your valuable feedback.

b. Reviewer #5 Comments: Avoid extraneous details in the discussion. There was too much written about the study tool in the discussion that should be cut or moved to the methods section Thank you very much. Details were presented about the SDQ to the methods section. As the given comment we provided a brief overview in the discussion. We have streamlined the discussion and focused on the key findings and implications of our study removing the extraneous details(page23 line 432-442)

c. Reviewer #5 Comments: It is curious that a multivariable analysis was not done to test the independence of the observed association between mental health literacy and wellbeing and mental health problems, when several variables that were in your dataset (like age and proxies for socioeconomic status) could easily be confounders. I strongly recommend performing this analysis. Thank you for your valuable feedback regarding the inclusion of a multivariable analysis in our study. We understand your recommendation and acknowledge the potential benefits of such an analysis in controlling for confounding variables.

While we agree that a multivariable analysis could provide additional insights into the relationship between mental health literacy, well-being, and mental health problems, we believe that the extensive number of tables required for such an analysis would exceed the limitations imposed by PLOS ONE.

However, we have carefully considered your suggestion and plan to include a multivariable analysis in a future study with a larger sample size. This will allow us to more comprehensively explore the complex relationships between these variables and provide a deeper understanding of the factors influencing adolescent mental health.

We include recommendation that reads “Future studies with larger sample sizes should conduct multivariable analyses to further explore the complex relationships between mental health literacy, well-being, and mental health problems while controlling for potential confounding factors” (Page29 Line 637-640)

We believe that the correlation analysis presented in this study provides a valuable foundation for future research and contributes significantly to our understanding of the topic. Thank you again for your insightful comments.

d. Reviewer #5 Comments: I recommend that the authors seek independent editing of the manuscript. Thank you for your valuable feedback and recommendation for independent editing. We have carefully considered your suggestion and have taken steps to enhance the clarity and coherence of our manuscript.

In addition to the independent editing conducted by a colleague, all authors have engaged in a thorough review and revision process. We have carefully examined the discussion section and have made necessary adjustments to ensure that our statements are clear, concise, and supported by the evidence presented in the study.

We believe that these combined efforts have significantly improved the overall quality and readability of our manuscript. We are confident that our revised work meets the high standards of your journal.

Thank you again for your time and consideration. We look forward to your further feedback.

Reviewer #6 Comments:

Thank you for the opportunity to review this work. The manuscript titled under review present important evidence for adolescent mental health in Africa and by extension low-middle income countries. It applied sound analytical approaches to answer the object of the study. However, the manuscript requires revisions before being accepted for publications.

Kindly find attached my review comments. Thank you for your valuable feedback on our manuscript. We appreciate your constructive comments and have carefully considered your comments. We have carefully addressed each of your specific comments and have provided detailed explanations for the changes we have made. Please refer to the revised manuscript for a comprehensive overview of these revisions.

Reviewer #6 Comments on Introduction section

a. Comment1 Page 5 paragraph 3: The description and justification of the SDQ and WHO wellbeing 5 should be included in the methods section when discussing the instruments used.

Thank you for your valuable feedback. We have carefully considered your comment regarding the placement of the description and justification of the SDQ and WHO-5 wellbeing index.

In response, we have removed the unnecessary repetition of these details from this section (page 5, lines 98-99) that is already incorporated into the methods section. We believe that this change enhances the clarity and organization of our manuscript.

We appreciate your continued attention to detail and your contributions to improving the quality of our work.

b. Comment2 Page 7: Study objective 3 “to examine the impact of socio-demographic characteristics on mental health issues” should be revised as the cross-sectional nature of the study does not allow for cause-and-effect relationships to be established. Also, the analytical framework used could only examine the association between socio-demographic characteristics and health issues. Thank you for your valuable feedback on our study objective 3. We acknowledge your comment that the cross-sectional nature of our study does not allow for the establishment of cause-and-effect relationships.

In response to your suggestion, we have revised study objective 3 to read as follows: "To examine the association between socio-demographic characteristics and mental health issues." This revised objective more accurately reflects the limitations of our study design and the nature of the analysis we conducted.

We believe that this revision addresses your concerns and provides a more accurate representation of our study's scope and limitations. (Page 7 line 167)

c. Comment3 Consider revising the introduction, be succinct and thoughts should follow in a logical sequence.

Thank you for your valuable feedback on our introduction. We acknowledge your suggestion to revise it for greater succinctness and logical flow. We have carefully reviewed the introduction and made the necessary adjustments removing unnecessary repetition of these details to ensure that our thoughts are presented in a clear and concise manner. (page 5, lines 98-99)

We believe that these revisions have significantly improved the clarity and coherence of our introduction. Thank you again for your helpful feedback

Reviewer #6 Comments on Results section

a. Comment1 It will be helpful to present a table on the socio-demographic characteristics of the participants before presenting other results. This should indicate the frequencies, percentage, and confidence intervals Page 11 - Table 1 should added to supplementary tables or removed from the manuscript. Thank you for your valuable feedback regarding the presentation of socio-demographic characteristics in our manuscript. We appreciate your suggestion to provide a more comprehensive overview of our participants' demographics.

In response to your comment, we have added a new Table 1 to the main body of the manuscript, presenting the socio-demographic characteristics of our participants, including frequencies and percentages. We believe that this table will enhance the clarity and understanding of our study's findings.

While we have added Table 1 as you suggested with descriptions (Page 10-11 line 257-286), and we have retained table 1 from previous version. We believe that the information contained in Table 2 (current version) remains crucial for a deeper understanding of our research and its implications providing context and details for the readers. Previous tables number 1,2,3, and 4 became table 2,3,4 and 5 in the current version. We hope that these revisions address your concerns and improve the overall quality of our manuscript. Thank you again for your

b. Comment2 Page 13- the prevalence estimates as stated in the manuscript does not correspond with results in fig 1. E.g. Prevalence of total difficulties ranged from 14.0%-24.5% not “15.9-25.5%”, internalizing 14.9-28.8% not “14.8-28.4%” Please check and revise all the results in the manuscript. Thank you for your careful review of our manuscript. We appreciate your attention to detail and your insightful comments. We have carefully reviewed your comment regarding the discrepancies between the prevalence estimates reported in the text and those depicted in Figure 1. You are absolutely correct. There were errors in the text.

We have thoroughly checked and corrected all the prevalence estimates in the manuscript to accurately reflect the data presented in Figure 1. The revised manuscript now includes the correct prevalence estimates for total difficulties, internalizing difficulties, and other relevant variables. We believe that these changes have strengthened the clarity and accuracy of our findings. (Page 14 line 296, 297& 301)

c. Comment3 Report the results in table 2 in the manuscript. Provide a description beneath the table for “a” as denoted in the table. Thank you for your valuable feedback. We have carefully considered your comments and have revised the manuscript accordingly. Your suggestion to report the results in Table 2 [current version of the manuscript table 3 because of addition of a table] was addressed providing more. (Page 17 line 320-327). We believe this enhancement will improve the clarity and understanding of our findings."

d. Comment4 “It was twice higher among adolescents with a self and family members experiencing psychoactive substance use (p0.05)” … state the AOR and CI’s. Thank you for your careful review of our manuscript. We apologize for any ove

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Decision Letter 3

Yared Reta Abayneh

9 Oct 2024

Mental health issues and the association of mental health literacy among adolescents in urban Ethiopia

PONE-D-23-13300R3

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Acceptance letter

Yared Reta Abayneh

15 Oct 2024

PONE-D-23-13300R3

PLOS ONE

Dear Dr. Hassen,

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PLOS ONE

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