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. 1991 Jan 1;273(Pt 1):241–243. doi: 10.1042/bj2730241

Neomycin does not interfere with the inositol phospholipid metabolism, but blocks binding of alpha-thrombin to intact human platelets.

O B Tysnes 1, E Johanessen 1, V M Steen 1
PMCID: PMC1150214  PMID: 1846529

Abstract

Neomycin was demonstrated to inhibit the binding of thrombin to intact human platelets. The effects of neomycin on both thrombin binding and thrombin-induced changes in inositol phospholipid metabolism could be reproduced by the thrombin antagonist hirudin. We propose that neomycin inhibits thrombin-induced platelet activation by interference with the cellular receptor.

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Selected References

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