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. 1991 Jun 1;276(Pt 2):343–347. doi: 10.1042/bj2760343

Inflammation-induced changes in expression and glycosylation of genetic variants of alpha 1-acid glycoprotein. Studies with human sera, primary cultures of human hepatocytes and transgenic mice.

W van Dijk 1, O Pos 1, M E van der Stelt 1, H J Moshage 1, S H Yap 1, L Dente 1, P Baumann 1, C B Eap 1
PMCID: PMC1151097  PMID: 1646598

Abstract

The relative occurrence of genetic variants of human alpha 1-acid glycoprotein (AGP) in relation to changes in glycosylation was studied in sera of patients with burn injury, media of cytokine-treated primary cultures of human hepatocytes and Hep 3B cells, and sera of transgenic mice expressing the human AGP-A gene. It is concluded (i) that the glycosylation of AGP was not dependent on its genetic expression and (ii) that both the variants determined by the AGP-A gene as well as by the AGP-B/B' genes are increased after inflammation or treatment with interleukins 1 and 6.

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Selected References

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