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. 1991 Aug 1;277(Pt 3):899–902. doi: 10.1042/bj2770899

Transmitter regulation of voltage-dependent K+ channels expressed in Xenopus oocytes.

M P Kavanaugh 1, M J Christie 1, P B Osborne 1, A E Busch 1, K Z Shen 1, Y N Wu 1, P H Seeburg 1, J P Adelman 1, R A North 1
PMCID: PMC1151331  PMID: 1651707

Abstract

Voltage-dependent K+ channels (RBK1, RBK2 and RGK5) were co-expressed in Xenopus oocytes with 5-hydroxytryptamine (5-HT2) receptors. K+ currents measured 2-4 days later were inhibited by 5-HT (100 nM-10 microM, 20-30 s application) by up to 90%. The effect of 5-HT was mimicked by intracellular injection of Ins(1,4,5)P3. Increasing the Ca2+ concentration at the inner surface of excised membrane patches did not decrease the K+ current.

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Selected References

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