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. 1991 Nov 1;279(Pt 3):895–897. doi: 10.1042/bj2790895

Effect of carboxylic acid xenobiotics and their metabolites on the activity of carnitine acyltransferases.

D A Vessey 1, W W Chen 1, R R Ramsay 1
PMCID: PMC1151530  PMID: 1953685

Abstract

Salicylyl-CoA and benzoyl-CoA were good inhibitors of carnitine acetyltransferase (CAT), competing with acetyl-CoA with Ki values of 7.5 and 22 microM respectively in the forward direction and with CoA in the reverse reaction with similar Ki values. They were also competitive inhibitors of carnitine octanoyltransferase (Ki = 261 and 295 microM respectively), but were only weakly inhibitory to carnitine palmitoyltransferase. Inhibition of energy production by salicylate may result from the inhibition of CAT by salicylyl-CoA.

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Selected References

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