Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Oct 21;55(11):2705–2715. doi: 10.1161/STROKEAHA.124.048264

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2024 The Authors.

Stroke is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

PMC Copyright notice

Figure 1. — Caffeine pharmacokinetics and effects on resuscitation. A, Caffeine concentration in ewe (n=6) and lamb (n=7) plasma at the time of umbilical cord occlusion and caffeine concentration in lamb (n=7) plasma over time. B, Hemodynamic changes in response to umbilical cord occlusion (UCO) with drop in systolic blood pressure (SBP) and mean arterial pressure (MAP) followed by increase reflecting return of spontaneous circulation (ROSC). Hemodynamic data were analyzed using grouped analysis of the individual group’s means for a specific time point. Placebo (P): n=19; low-dose (LD) caffeine: n=14; and high-dose (HD) caffeine: n=7. C, Time to asystole and time to ROSC were similar among the compared groups. Groups were compared using the Kruskal-Wallis test. Placebo: n=21; LD caffeine: n=18–19; and HD caffeine: n=8. D, Selected anthropometric parameters between the studied groups. Brain and body weight differences were assessed using ANOVA. Data in graph B are shown as mean and graph C and D as mean±SEM. Placebo: n=20–21; LD caffeine: n=16–19; and HD caffeine: n=5–8. LD-caffeine–treated group is presented in green, HD-caffeine–treated group is presented in red, and placebo is presented in black. *P<0.05. wt indicates weight.