Figure 3.

Representative cryo-imaging and CE-MRI image volumes of mice with U251 tumors 40 and 90 min after agent administration. Same structure as presented in Figure 2, each row shows data for one animal. (A-D) Show images of animals 40 min after agent administration. In (A) and (B), columns from left to right show the RGB rendering with tumor and normal brain surfaces, TMR-PEG1k, IRDye800CW, Early CE-MRI and T.M. CE-MRI. (C) and (D) shows images of animals administered TMR-PEG550 and IRDye800CW with an analogous column arrangement to (A) and (B). (E) and (F) show images of animals 90 min after administration of TMR-PEG1k and ICG. Units for fluorescence volumes are relative fluorescence units (RFU). Thresholding and units are identical to those used in Figure 2.