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. 1983 Apr 15;212(1):167–171. doi: 10.1042/bj2120167

The interaction between lipid peroxidation and prostaglandin synthesis in rabbit kidney-medulla slices.

Y Fujimoto, H Tanioka, I Keshi, T Fujita
PMCID: PMC1152025  PMID: 6575779

Abstract

Lipid peroxidation induced by ascorbic acid and Fe2+ was inhibited by mepacrine (phospholipase A2 inhibitor) and aspirin (prostaglandin cyclo-oxygenase inhibitor) in rabbit kidney-medulla slices. Moreover, ascorbic acid and Fe2+ potentiated the inhibitory effect on prostaglandin E2 formation by mepacrine, but they had no influence on prostaglandin E2 production decreased by aspirin. Lipid peroxidation induced by ascorbic acid and Fe2+ appears to be affecting the activity of prostaglandin endoperoxide synthase. These results suggest that lipid peroxidation is connected closely with the prostaglandin-generating system, and it has the potential to modulate the turnover of arachidonic acid and prostaglandin synthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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