Skip to main content
NCBI home page
Biochemical Journal logoLink to Biochemical Journal
. 1983 Apr 15;212(1):241–243. doi: 10.1042/bj2120241

Involvement of calcium ions in the activation of ornithine decarboxylase by isoprenaline evaluated 'in situ' in the perfused rat heart.

C Guarnieri, F Flamigni, C Muscari, C M Caldarera
PMCID: PMC1152035  PMID: 6409100

Abstract

Ornithine decarboxylase activity evaluated during the perfusion of isolated rat hearts by a method 'in situ' was rapidly increased when the hearts were infused with isoprenaline (isoproterenol). Omission of Ca2+ from the perfusion medium or the administration of verapamil to the perfused hearts decreased the isoprenaline-stimulated ornithine decarboxylase activity, whereas a marked stimulatory effect was registered when the hearts were perfused with the Ca2+ ionophore A23187.

Full text

PDF
241

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Canellakis Z. N., Theoharides T. C., Bondy P. K., Triarhos E. T. The role of calcium in the induction of ornithine decarboxylase in rat HTC cells. Life Sci. 1981 Aug 17;29(7):707–710. doi: 10.1016/0024-3205(81)90023-0. [DOI] [PubMed] [Google Scholar]
  2. Copeland J. G., Larson D. F., Roeske W. R., Russell D. H., Womble J. R. beta 2-Adrenoceptors regulate induction of myocardial ornithine decarboxylase in mice in vivo. Br J Pharmacol. 1982 Mar;75(3):479–483. doi: 10.1111/j.1476-5381.1982.tb09164.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Corti A., Casti A., Mezzetti G., Reali N., Orlandini G., Caldarera C. M. Modifications of major aspects of myocardial ribonucleic acid metabolism as a response to noradrenaline. Action of the hormone on cytoplasmic processing of ribonucleic acid after reserpine treatment. Biochem J. 1977 Dec 15;168(3):341–345. doi: 10.1042/bj1680341. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Costa M., Nye J. S. Calcium, asparagine and cAMP are required for ornithine decarboxylase activation in intact Chinese hamster ovary cells. Biochem Biophys Res Commun. 1978 Dec 14;85(3):1156–1164. doi: 10.1016/0006-291x(78)90663-0. [DOI] [PubMed] [Google Scholar]
  5. D'Amore P. A., Shepro D. Calcium flux and ornithine decarboxylase activity in cultured endothelial cells. Life Sci. 1978 Feb;22(7):571–576. doi: 10.1016/0024-3205(78)90335-1. [DOI] [PubMed] [Google Scholar]
  6. Fuller R. W., Hemrick S. K. Studies of noradrenergic influence on cardiac ornithine decarboxylase in rats. J Mol Cell Cardiol. 1978 Nov;10(11):1031–1036. doi: 10.1016/0022-2828(78)90399-1. [DOI] [PubMed] [Google Scholar]
  7. Gibbs J. B., Hsu C. Y., Terasaki W. L., Brooker G. Calcium and microtubule dependence for increased ornithine decarboxylase activity stimulated by beta-adrenergic agonists, dibutyryl cyclic AMP, or serum in a rat astrocytoma cell line. Proc Natl Acad Sci U S A. 1980 Feb;77(2):995–999. doi: 10.1073/pnas.77.2.995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Guarnieri C., Ferrari R., Visioli O., Caldarera C. M., Nayler W. G. Effect of alpha-tocopherol on hypoxic-perfused and reoxygenated rabbit heart muscle. J Mol Cell Cardiol. 1978 Oct;10(10):893–906. doi: 10.1016/0022-2828(78)90336-x. [DOI] [PubMed] [Google Scholar]
  9. Langer G. A., Serena S. D., Nudd L. M. Localization of contractile-dependent Ca: comparison of Mn and verapamil in cardiac and skeletal muslce. Am J Physiol. 1975 Oct;229(4):1003–1007. doi: 10.1152/ajplegacy.1975.229.4.1003. [DOI] [PubMed] [Google Scholar]
  10. Lau C., Slotkin T. A. Regulation of rat heart ornithine decarboxylase: change in affinity for ornithine evoked by neuronal, hormonal, and ontogenetic stimuli. Mol Pharmacol. 1979 Sep;16(2):504–512. [PubMed] [Google Scholar]
  11. Otani S., Kuramoto A., Matsui I., Morisawa S. Induction of ornithine decarboxylase in guinea pig lymphocytes by the divalent cation ionophore A 23187. Effect of dibutyryladenosine 3',5'-monophosphate. Eur J Biochem. 1982 Jun 15;125(1):35–40. doi: 10.1111/j.1432-1033.1982.tb06647.x. [DOI] [PubMed] [Google Scholar]
  12. Reed P. W., Lardy H. A. A23187: a divalent cation ionophore. J Biol Chem. 1972 Nov 10;247(21):6970–6977. [PubMed] [Google Scholar]
  13. Veldhuis J. D., Hammond J. M. Role of calcium in the modulation of ornithine decarboxylase activity in isolated pig granulosa cells in vitro. Biochem J. 1981 Jun 15;196(3):795–801. doi: 10.1042/bj1960795. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Veldhuis J. D., Harrison T. S., Hammond J. M. Beta-2-Adrenergic stimulation of ornithine decarboxylase activity in porcine granulosa cells in vitro. Biochim Biophys Acta. 1980 Jan 17;627(2):123–130. doi: 10.1016/0304-4165(80)90314-1. [DOI] [PubMed] [Google Scholar]
  15. Warnica J. W., Antony P., Gibson K., Harris P. The effect of isoprenaline and propranolol on rat myocardial ornithine decarboxylase. Cardiovasc Res. 1975 Nov;9(6):793–796. doi: 10.1093/cvr/9.6.793. [DOI] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES