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. 1983 May 15;212(2):521–524. doi: 10.1042/bj2120521

Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I.

T W Stephens, G A Cook, R A Harris
PMCID: PMC1152076  PMID: 6882380

Abstract

Malonyl-CoA inhibition of carnitine palmitoyltransferase I was found to be very pH-dependent. Malonyl-CoA concentrations causing 50% inhibition (I50) at pH 6.0, 6.5, 7.0, 7.5 and 8.0 were 0.04, 1, 9, 40 and 200 microM respectively. It is suggested that a lowering of intracellular pH, such as might occur in ketoacidosis, may attenuate hepatic fatty acid oxidation by increasing malonyl-CoA sensitivity of carnitine palmitoyltransferase I.

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Selected References

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