Skip to main content
Biochemical Journal logoLink to Biochemical Journal
. 1983 Jul 15;214(1):265–268. doi: 10.1042/bj2140265

GDP binding to brown-adipose-tissue mitochondria of mice treated chronically with corticosterone.

K S Galpin, R G Henderson, W P James, P Trayhurn
PMCID: PMC1152236  PMID: 6311176

Abstract

Cytochrome oxidase activity and mitochondrial GDP binding were decreased in brown adipose tissue of mice treated chronically with corticosterone. These changes occurred both in corticosterone-treated mice fed ad libitum and in treated mice pair-fed to control animals. Although the dietary stimulation of brown-adipose-tissue thermogenesis was suppressed by corticosterone, the acute response to cold was not affected.

Full text

PDF
265

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bray G. A. Regulation of energy balance: studies on genetic, hypothalamic and dietary obesity. Proc Nutr Soc. 1982 Jun;41(2):95–108. doi: 10.1079/pns19820018. [DOI] [PubMed] [Google Scholar]
  2. Bray G. A., York D. A. Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol Rev. 1979 Jul;59(3):719–809. doi: 10.1152/physrev.1979.59.3.719. [DOI] [PubMed] [Google Scholar]
  3. Cannon B., Lindberg O. Mitochondria from brown adipose tissue: isolation and properties. Methods Enzymol. 1979;55:65–78. doi: 10.1016/0076-6879(79)55010-1. [DOI] [PubMed] [Google Scholar]
  4. Deavers D. R., Musacchia X. J. The function of glucocorticoids in thermogenesis. Fed Proc. 1979 Jul;38(8):2177–2181. [PubMed] [Google Scholar]
  5. Feldman D. Evidence that brown adipose tissue is a glucocorticoid target organ. Endocrinology. 1978 Dec;103(6):2091–2097. doi: 10.1210/endo-103-6-2091. [DOI] [PubMed] [Google Scholar]
  6. Goodbody A. E., Trayhurn P. GDP binding to brown-adipose-tissue mitochondria of diabetic--obese (db/db) mice. Decreased binding in both the obese and pre-obese states. Biochem J. 1981 Mar 15;194(3):1019–1022. doi: 10.1042/bj1941019. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Goodbody A. E., Trayhurn P. Studies on the activity of brown adipose tissue in suckling, pre-obese, ob/ob mice. Biochim Biophys Acta. 1982 May 19;680(2):119–126. doi: 10.1016/0005-2728(82)90002-0. [DOI] [PubMed] [Google Scholar]
  8. Hervey G. R., Tobin G. The part played by variation of energy expenditure in the regulation of energy balance. Proc Nutr Soc. 1982 Jun;41(2):137–153. doi: 10.1079/pns19820024. [DOI] [PubMed] [Google Scholar]
  9. Himms-Hagen J., Desautels M. A mitochondrial defect in brown adipose tissue of the obese (ob/ob) mouse: reduced binding of purine nucleotides and a failure to respond to cold by an increase in binding. Biochem Biophys Res Commun. 1978 Jul 28;83(2):628–634. doi: 10.1016/0006-291x(78)91036-7. [DOI] [PubMed] [Google Scholar]
  10. Hogan S., Coscina D. V., Himms-Hagen J. Brown adipose tissue of rats with obesity-inducing ventromedial hypothalamic lesions. Am J Physiol. 1982 Oct;243(4):E338–E344. doi: 10.1152/ajpendo.1982.243.4.E338. [DOI] [PubMed] [Google Scholar]
  11. Hogan S., Himms-Hagen J. Abnormal brown adipose tissue in obese (ob/ob) mice: response to acclimation to cold. Am J Physiol. 1980 Oct;239(4):E301–E309. doi: 10.1152/ajpendo.1980.239.4.E301. [DOI] [PubMed] [Google Scholar]
  12. Holt S., York D. A. The effect of adrenalectomy on GDP binding to brown-adipose-tissue mitochondria of obese rat. Biochem J. 1982 Dec 15;208(3):819–822. doi: 10.1042/bj2080819. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Nicholls D. G. Brown adipose tissue mitochondria. Biochim Biophys Acta. 1979 Jul 3;549(1):1–29. doi: 10.1016/0304-4173(79)90016-8. [DOI] [PubMed] [Google Scholar]
  14. Rothwell N. J., Stock M. J. A role for brown adipose tissue in diet-induced thermogenesis. Nature. 1979 Sep 6;281(5726):31–35. doi: 10.1038/281031a0. [DOI] [PubMed] [Google Scholar]
  15. Schacterle G. R., Pollack R. L. A simplified method for the quantitative assay of small amounts of protein in biologic material. Anal Biochem. 1973 Feb;51(2):654–655. doi: 10.1016/0003-2697(73)90523-x. [DOI] [PubMed] [Google Scholar]
  16. Thurlby P. L., Trayhurn P. Regional blood flow in genetically obese (ob/ob) mice. The importance of brown adipose tissue to the reduced energy expenditure on non-shivering thermogenesis. Pflugers Arch. 1980 Jun;385(3):193–201. doi: 10.1007/BF00647457. [DOI] [PubMed] [Google Scholar]
  17. Trayhurn P., Jones P. M., McGuckin M. M., Goodbody A. E. Effects of overfeeding on energy balance and brown fat thermogenesis in obese (ob/ob) mice. Nature. 1982 Jan 28;295(5847):323–325. doi: 10.1038/295323a0. [DOI] [PubMed] [Google Scholar]
  18. YONETANI T., RAY G. S. STUDIES ON CYTOCHROME OXIDASE. VI. KINETICS OF THE AEROBIC OXIDATION OF FERROCYTOCHROME C BY CYTOCHROME OXIDASE. J Biol Chem. 1965 Aug;240:3392–3398. [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES