Abstract
For the inhibition of spontaneous N epsilon-methylation and N epsilon-formylation reactions between L-lysine and formaldehyde, L-ascorbic acid proved to be most suitable. The inhibition was not complete unless the molar concentration of ascorbic acid exceeded that of formaldehyde. T.l.c., potentiometric titration, n.m.r. spectroscopy and radiometric analysis were applied in the study of the inhibition process. Formaldehyde was reduced by L-ascorbic acid to ethylene glycol.
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- Cameron E., Pauling L., Leibovitz B. Ascorbic acid and cancer: a review. Cancer Res. 1979 Mar;39(3):663–681. [PubMed] [Google Scholar]
- Johansson E. B., Tjälve H. The distribution of [14C]dimethylnitrosamine in mice. Autoradiographic studies in mice with inhibited and noninhibited dimethylnitrosamine metabolism and a comparison with the distribution of [14C]formaldehyde. Toxicol Appl Pharmacol. 1978 Aug;45(2):565–575. doi: 10.1016/0041-008x(78)90118-7. [DOI] [PubMed] [Google Scholar]
- Paik W. K., Kim S. Epsilon-alkyllysinase. New assay method, purification, and biological significance. Arch Biochem Biophys. 1974 Nov;165(1):369–378. doi: 10.1016/0003-9861(74)90175-1. [DOI] [PubMed] [Google Scholar]
- Suba Z., Szende B., Lapis K., Takács J., Elek G. epsilon-N-trimethyl-lysine: a natural cell component with mitogenic activity. Neoplasma. 1980;27(1):11–23. [PubMed] [Google Scholar]
- Turberville C., Craddock V. M. Methylation of nuclear proteins by dimethylnitrosamine and by methionine in the rat in vivo. Biochem J. 1971 Oct;124(4):725–739. doi: 10.1042/bj1240725. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tyihák E., Szende B., Lapis K. Biological significance of methylated derivatives of lysine and arginine. Life Sci. 1977 Feb 1;20(3):385–392. doi: 10.1016/0024-3205(77)90378-2. [DOI] [PubMed] [Google Scholar]
- Tyihák E., Trézl L., Rusznák I. Spontaneous N epsilon-methylation of L-lysine by formaldehyde. Pharmazie. 1980 Jan;35(1):18–20. [PubMed] [Google Scholar]