Skip to main content
NCBI home page
Biochemical Journal logoLink to Biochemical Journal
. 1983 Sep 15;214(3):1007–1009. doi: 10.1042/bj2141007

UDP-glucuronyltransferase activity exhibits two developmental groups in liver from foetal rhesus monkeys.

J E Leakey, Z R Althaus, J R Bailey, W Slikker Jr
PMCID: PMC1152346  PMID: 6414458

Abstract

UDP-glucuronyltransferase was assayed in liver from adult rhesus monkeys and foetuses during late gestation. Activities toward 2-aminophenol, 5-hydroxytryptamine, 1-naphthol and 4-nitrophenol in the foetal liver ranged from 46 to 114% of adult values, whereas activities toward bilirubin, oestradiol and testosterone were less than 5% of adult values. This suggests that in primates UDP-glucuronyltransferase develops differentially in two clusters analogous to that in the rat.

Full text

PDF
1007

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Burchell B., Leakey J., Dutton G. J. Relationship beteen activation of "detoxicating" enzymes in stored broken-cell preparations and in autolysing liver. Enzyme. 1975;20(3):156–164. doi: 10.1159/000458934. [DOI] [PubMed] [Google Scholar]
  2. Dutton G. J., Leakey J. E., Pollard M. R. Assays for UDPglucuronyltransferase activities. Methods Enzymol. 1981;77:383–391. doi: 10.1016/s0076-6879(81)77051-4. [DOI] [PubMed] [Google Scholar]
  3. Dutton G. J., Leakey J. E. The perinatal development of drug-metabolizing enzymes: what factors trigger their onset? Prog Drug Res. 1981;25:189–273. [PubMed] [Google Scholar]
  4. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  5. Leakey J. E. An improved assay technique for uridine diphosphate glucuronosyltransferase activity towards 5-hydroxytryptamine and some properties of the enzyme. Biochem J. 1978 Dec 1;175(3):1119–1124. doi: 10.1042/bj1751119. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Onishi S., Kawade N., Itoh S., Isobe K., Sugiyama S. Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver. Biochem J. 1979 Dec 15;184(3):705–707. doi: 10.1042/bj1840705. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Rao G. S., Haueter G., Rao M. L., Breuer H. An improved assay for steroid glucuronyltransferase in rat liver microsomes. Anal Biochem. 1976 Jul;74(1):35–40. doi: 10.1016/0003-2697(76)90307-9. [DOI] [PubMed] [Google Scholar]
  8. Slikker W., Jr, Bailey J. R., Newport D., Lipe G. W., Hill D. E. Placental transfer and metabolism of 17 alpha-ethynylestradiol-17 beta and estradiol-17 beta in the rhesus monkey. J Pharmacol Exp Ther. 1982 Nov;223(2):483–489. [PubMed] [Google Scholar]
  9. Van Roy F. P., Heirwegh K. P. Determination of bilirubin glucuronide and assay of glucuronyltransferase with bilirubin as acceptor. Biochem J. 1968 Apr;107(4):507–518. doi: 10.1042/bj1070507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Wishart G. J. Functional heterogeneity of UDP-glucuronosyltransferase as indicated by its differential development and inducibility by glucocorticoids. Demonstration of two groups within the enzyme's activity towards twelve substrates. Biochem J. 1978 Aug 15;174(2):485–489. doi: 10.1042/bj1740485. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES