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. 1983 Dec 1;215(3):693–696. doi: 10.1042/bj2150693

The storage products in genetic and swainsonine-induced human mannosidosis.

I Cenci di Bello, P Dorling, B Winchester
PMCID: PMC1152453  PMID: 6419731

Abstract

Swainsonine induces the accumulation of mannose-rich oligosaccharides in human fibroblasts. The composition of the storage products shows that swainsonine completely inhibits lysosomal alpha-D-mannosidase and alters processing of glycoproteins by inhibiting Golgi alpha-D-mannosidase II. Comparison of the storage products in genetic and swainsonine-induced mannosidosis suggests that human fibroblasts contain a lysosomal alpha-D-mannosidase that is unaffected in genetic mannosidosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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