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. 1983 Nov 15;216(2):491–494. doi: 10.1042/bj2160491

Defective activation by glucose of hepatic glycogen synthesis in the obese hyperglycaemic mouse.

S A Smith, M A Cawthorne, A L Levy, D L Simson
PMCID: PMC1152528  PMID: 6419733

Abstract

The administration of an oral glucose load to 24 h-starved lean (+/?) male C57BL/6 mice produced a rapid, 7-fold increase in the rate of hepatic glycogen synthesis and a sustained activation of glycogen synthase. In contrast, glucose produced only a small (4.5-fold), short-lived increase in hepatic glycogen synthesis in genetically obese (ob/ob) mice and no activation of glycogen synthase.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Das I., Hems D. A. Glycogen synthetase and phosphorylase activities in different tissues of genetically obese mice. Horm Metab Res. 1974 Jan;6(1):40–44. doi: 10.1055/s-0028-1093901. [DOI] [PubMed] [Google Scholar]
  2. Elliott J., Hems D. A., Beloff-Chain A. Carbohydrate metabolism of the isolated perfused liver of normal and genetically obese--hyperglycaemic (ob-ob) mice. Biochem J. 1971 Dec;125(3):773–780. doi: 10.1042/bj1250773. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Felig P., Wahren J., Hendler R. Influence of maturity-onset diabetes on splanchnic glucose balance after oral glucose ingestion. Diabetes. 1978 Feb;27(2):121–126. doi: 10.2337/diab.27.2.121. [DOI] [PubMed] [Google Scholar]
  4. Felig P., Wahren J., Hendler R. Influence of oral glucose ingestion on splanchnic glucose and gluconeogenic substrate metabolism in man. Diabetes. 1975 May;24(5):468–475. doi: 10.2337/diab.24.5.468. [DOI] [PubMed] [Google Scholar]
  5. Katz J., Golden S., Wals P. A. Glycogen synthesis by rat hepatocytes. Biochem J. 1979 May 15;180(2):389–402. doi: 10.1042/bj1800389. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kreutner W., Springer S. C., Sherwood J. E. Resistance of gluconeogenic and glycogenic pathways in obese-hyperglycemic mice. Am J Physiol. 1975 Feb;228(2):663–671. doi: 10.1152/ajplegacy.1975.228.2.663. [DOI] [PubMed] [Google Scholar]
  7. Loten E. G., Assimacopoulos-Jeannet F., Le Marchand Y., Singh A., Jeanrenaud B. Regulation of carbohydrate and lipid metabolism in the liver and adipose tissue of normal and diabetic mice. Adv Enzyme Regul. 1974;12:45–71. doi: 10.1016/0065-2571(74)90006-5. [DOI] [PubMed] [Google Scholar]
  8. Postle A. D., Bloxham D. P. The use of tritiated water to measure absolute rates of hepatic glycogen synthesis. Biochem J. 1980 Oct 15;192(1):65–73. doi: 10.1042/bj1920065. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Rognstad R., Clark G., Katz J. Glucose synthesis in tritiated water. Eur J Biochem. 1974 Sep 1;47(2):383–388. doi: 10.1111/j.1432-1033.1974.tb03703.x. [DOI] [PubMed] [Google Scholar]
  10. SCHMIDT F. H. [Enzymatic determination of glucose and fructose simultaneously]. Klin Wochenschr. 1961 Dec 1;39:1244–1247. doi: 10.1007/BF01506150. [DOI] [PubMed] [Google Scholar]
  11. Sestoft L., Hue L. Gastrointestinal mediator of insulin action. Lancet. 1980 Mar 22;1(8169):662–663. [PubMed] [Google Scholar]
  12. Stalmans W., De Wulf H., Hue L., Hers H. G. The sequential inactivation of glycogen phosphorylase and activation of glycogen synthetase in liver after the administration of glucose to mice and rats. The mechanism of the hepatic threshold to glucose. Eur J Biochem. 1974 Jan 3;41(1):127–134. doi: 10.1111/j.1432-1033.1974.tb03252.x. [DOI] [PubMed] [Google Scholar]
  13. Stalmans W. The role of the liver in the homeostasis of blood glucose. Curr Top Cell Regul. 1976;11:51–97. doi: 10.1016/b978-0-12-152811-9.50009-2. [DOI] [PubMed] [Google Scholar]
  14. Thomas J. A., Schlender K. K., Larner J. A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose. Anal Biochem. 1968 Oct 24;25(1):486–499. doi: 10.1016/0003-2697(68)90127-9. [DOI] [PubMed] [Google Scholar]
  15. de Wulf H., Hers H. G. The interconversion of liver glycogen synthetase a and b in vitro. Eur J Biochem. 1968 Dec 5;6(4):552–557. doi: 10.1111/j.1432-1033.1968.tb00480.x. [DOI] [PubMed] [Google Scholar]

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