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. 1983 Dec 15;216(3):583–587. doi: 10.1042/bj2160583

The role of insulin, corticosterone and other factors in the acute recovery of muscle protein synthesis on refeeding food-deprived rats.

D J Millward, B Odedra, P C Bates
PMCID: PMC1152549  PMID: 6365077

Abstract

Measurements of changes in muscle protein synthesis, insulin and corticosterone in vivo in refed food-deprived rats, some after pretreatment with anti-insulin serum or corticosterone, indicate that the acute increase in protein synthesis (20-40 min) requires (a) insulin, (b) a fall in corticosterone, since corticosterone acts at least in part by blocking insulin action, and (c) at least one other independent anabolic factor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown J. G., Millward D. J. Dose response of protein turnover in rat skeletal muscle to triiodothyronine treatment. Biochim Biophys Acta. 1983 May 25;757(2):182–190. doi: 10.1016/0304-4165(83)90107-1. [DOI] [PubMed] [Google Scholar]
  2. Brown J. G., van Bueren J., Millward D. J. The effect of tri-iodothyronine administration on protein synthesis in the diabetic rat. Biochem J. 1983 Aug 15;214(2):637–640. doi: 10.1042/bj2140637. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Garlick P. J., Fern M., Preedy V. R. The effect of insulin infusion and food intake on muscle protein synthesis in postabsorptive rats. Biochem J. 1983 Mar 15;210(3):669–676. doi: 10.1042/bj2100669. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Garlick P. J., McNurlan M. A., Preedy V. R. A rapid and convenient technique for measuring the rate of protein synthesis in tissues by injection of [3H]phenylalanine. Biochem J. 1980 Nov 15;192(2):719–723. doi: 10.1042/bj1920719. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Garlick P. J., Millward D. J., James W. P. The diurnal response of muscle and liver protein synthesis in vivo in meal-fed rats. Biochem J. 1973 Dec;136(4):935–945. doi: 10.1042/bj1360935. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Goldberg A. L. Influence of insulin and contractile activity on muscle size and protein balance. Diabetes. 1979 Jan;28 (Suppl 1):18–24. doi: 10.2337/diab.28.1.s18. [DOI] [PubMed] [Google Scholar]
  7. Henshaw E. C., Hirsch C. A., Morton B. E., Hiatt H. H. Control of protein synthesis in mammalian tissues through changes in ribosome activity. J Biol Chem. 1971 Jan 25;246(2):436–446. [PubMed] [Google Scholar]
  8. Jefferson L. S. Lilly Lecture 1979: role of insulin in the regulation of protein synthesis. Diabetes. 1980 Jun;29(6):487–496. doi: 10.2337/diab.29.6.487. [DOI] [PubMed] [Google Scholar]
  9. Mathews R. W., Oronsky A., Haschemeyer A. E. Effect of thyroid hormone on polypeptide chain assembly kinetics in liver protein synthesis in vivo. J Biol Chem. 1973 Feb 25;248(4):1329–1333. [PubMed] [Google Scholar]
  10. McNurlan M. A., Fern E. B., Garlick P. J. Failure of leucine to stimulate protein synthesis in vivo. Biochem J. 1982 Jun 15;204(3):831–838. doi: 10.1042/bj2040831. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Millward D. J., Garlick P. J., James W. P., Nnanyelugo D. O., Ryatt J. S. Relationship between protein synthesis and RNA content in skeletal muscle. Nature. 1973 Jan 19;241(5386):204–205. doi: 10.1038/241204a0. [DOI] [PubMed] [Google Scholar]
  12. Millward D. J., Garlick P. J., Nnanyelugo D. O., Waterlow J. C. The relative importance of muscle protein synthesis and breakdown in the regulation of muscle mass. Biochem J. 1976 Apr 15;156(1):185–188. doi: 10.1042/bj1560185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Millward D. J., Nnanyelugo D. O., James W. P., Garlick P. J. Protein metabolism in skeletal muscle: the effect of feeding and fasting on muscle RNA, free amino acids and plasma insulin concentrations. Br J Nutr. 1974 Jul;32(1):127–142. doi: 10.1079/bjn19740063. [DOI] [PubMed] [Google Scholar]
  14. Millward D. J., Waterlow J. C. Effect of nutrition on protein turnover in skeletal muscle. Fed Proc. 1978 Jul;37(9):2283–2290. [PubMed] [Google Scholar]
  15. Odedra B. R., Bates P. C., Millward D. J. Time course of the effect of catabolic doses of corticosterone on protein turnover in rat skeletal muscle and liver. Biochem J. 1983 Aug 15;214(2):617–627. doi: 10.1042/bj2140617. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Odedra B. R., Dalal S. S., Millward D. J. Muscle protein synthesis in the streptozotocin-diabetic rat. A possible role for corticosterone in the insensitivity to insulin infusion in vivo. Biochem J. 1982 Feb 15;202(2):363–368. doi: 10.1042/bj2020363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Odedra B. R., Millward D. J. Effect of corticosterone treatment on muscle protein turnover in adrenalectomized rats and diabetic rats maintained on insulin. Biochem J. 1982 Jun 15;204(3):663–672. doi: 10.1042/bj2040663. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Pain V. M., Garlick P. J. Effect of streptozotocin diabetes and insulin treatment on the rate of protein synthesis in tissues of the rat in vivo. J Biol Chem. 1974 Jul 25;249(14):4510–4514. [PubMed] [Google Scholar]
  19. Rennie M. J., Edwards R. H., Halliday D., Matthews D. E., Wolman S. L., Millward D. J. Muscle protein synthesis measured by stable isotope techniques in man: the effects of feeding and fasting. Clin Sci (Lond) 1982 Dec;63(6):519–523. doi: 10.1042/cs0630519. [DOI] [PubMed] [Google Scholar]

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