Skip to main content
NCBI home page
Biochemical Journal logoLink to Biochemical Journal
. 1985 Nov 15;232(1):301–304. doi: 10.1042/bj2320301

Adenosine effects on glucose oxidation of adipocytes isolated from streptozotocin-diabetic rats.

E H Wong, J A Smith, L Jarett
PMCID: PMC1152876  PMID: 3910029

Abstract

Streptozotocin-induced diabetes did not impair the response of adipocytes to adenosine effects in glucose oxidation. The greatest effect of adenosine in potentiating the action of insulin was in the physiological concentration range of insulin (10-100 mu units/ml). The desensitization of cells by diabetes to the effects of insulin is therefore probably not related to the response of cells to adenosine.

Full text

PDF
301

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Fain J. N. Inhibition of adenosine cyclic 3', 5'-monophosphate accumulation in fat cells by adenosine, N6-(phenylisopropyl) adenosine, and related compounds. Mol Pharmacol. 1973 Sep;9(5):595–604. [PubMed] [Google Scholar]
  2. Fain J. N., Wieser P. B. Effects of adenosine deaminase on cyclic adenosine monophosphate accumulation, lipolysis, and glucose metabolism of fat cells. J Biol Chem. 1975 Feb 10;250(3):1027–1034. [PubMed] [Google Scholar]
  3. Gliemann J. Assay of insulin-like activity by the isolated fat cell method. I. Factors influencing the response to crystalline insulin. Diabetologia. 1967 Aug;3(4):382–388. doi: 10.1007/BF02342631. [DOI] [PubMed] [Google Scholar]
  4. Green A. Catecholamines inhibit insulin-stimulated glucose transport in adipocytes, in the presence of adenosine deaminase. FEBS Lett. 1983 Feb 21;152(2):261–264. doi: 10.1016/0014-5793(83)80392-5. [DOI] [PubMed] [Google Scholar]
  5. Green A., Newsholme E. A. Sensitivity of glucose uptake and lipolysis of white adipocytes of the rat to insulin and effects of some metabolites. Biochem J. 1979 May 15;180(2):365–370. doi: 10.1042/bj1800365. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Honeyman T. W., Strohsnitter W., Scheid C. R., Schimmel R. J. Phosphatidic acid and phosphatidylinositol labelling in adipose tissue. Relationship to the metabolic effects of insulin and insulin-like agents. Biochem J. 1983 May 15;212(2):489–498. doi: 10.1042/bj2120489. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Joost H. G., Steinfelder H. J. Modulation of insulin sensitivity by adenosine. Effects on glucose transport, lipid synthesis, and insulin receptors of the adipocyte. Mol Pharmacol. 1982 Nov;22(3):614–618. [PubMed] [Google Scholar]
  8. Londos C., Cooper D. M., Schlegel W., Rodbell M. Adenosine analogs inhibit adipocyte adenylate cyclase by a GTP-dependent process: basis for actions of adenosine and methylxanthines on cyclic AMP production and lipolysis. Proc Natl Acad Sci U S A. 1978 Nov;75(11):5362–5366. doi: 10.1073/pnas.75.11.5362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Nakhoda A., Wong H. A. The induction of diabetes in rats by intramuscular administration of streptozotocin. Experientia. 1979 Dec 15;35(12):1679–1680. doi: 10.1007/BF01953269. [DOI] [PubMed] [Google Scholar]
  10. RODBELL M. METABOLISM OF ISOLATED FAT CELLS. I. EFFECTS OF HORMONES ON GLUCOSE METABOLISM AND LIPOLYSIS. J Biol Chem. 1964 Feb;239:375–380. [PubMed] [Google Scholar]
  11. Raess B. U., Muchmore D. B., de Haën C. Glycogen synthesis stimulation by adenylate cyclase inhibition in rat epididymal adipocytes. Biochemistry. 1983 Apr 26;22(9):2214–2221. doi: 10.1021/bi00278a024. [DOI] [PubMed] [Google Scholar]
  12. Sauerheber R. D., Kuhn C. E., Hyslop P. A. Membrane structural/functional properties of adipocytes from normal and streptozotocin-diabetic rats. Diabetes. 1984 Mar;33(3):258–265. doi: 10.2337/diab.33.3.258. [DOI] [PubMed] [Google Scholar]
  13. Schimmel R. J., Honeyman T. W., McMahon K. K., Serio R., Clark R. B. Inhibition of cyclic AMP accumulation in hamster adipocytes with phosphatidic acid: differences and similarities with alpha adrenergic effects. J Cyclic Nucleotide Res. 1980;6(6):437–449. [PubMed] [Google Scholar]
  14. Schwabe U., Ebert R., Erbler H. C. Adenosine release from isolated fat cells and its significance for the effects of hormones on cyclic 3',5'-AMP levels and lipolysis. Naunyn Schmiedebergs Arch Pharmacol. 1973;276(2):133–148. doi: 10.1007/BF00501186. [DOI] [PubMed] [Google Scholar]
  15. Schwabe U., Schönhöfer P. S., Ebert R. Facilitation by adenosine of the action of insulin on the accumulation of adenosine 3':5'-monophosphate, lipolysis, and glucose oxidation in isolated fat cells. Eur J Biochem. 1974 Aug 1;46(3):537–545. doi: 10.1111/j.1432-1033.1974.tb03647.x. [DOI] [PubMed] [Google Scholar]
  16. Teo T. S., Ooi S. O., Wong E. H. Stimulation of rat fat cell phosphodiesterase by adenosine. FEBS Lett. 1981 Jun 1;128(1):75–78. doi: 10.1016/0014-5793(81)81083-6. [DOI] [PubMed] [Google Scholar]
  17. Trost T., Schwabe U. Adenosine receptors in fat cells. Identification by (-)-N6-[3H]phenylisopropyladenosine binding. Mol Pharmacol. 1981 Mar;19(2):228–235. [PubMed] [Google Scholar]
  18. Wong E. H., Loten E. G. The antilipolytic action of insulin on adrenocorticotrophin-stimulated rat adipocytes. The roles of adenosine 3',5'-monophosphate and the protein kinase dependent on adenosine 3',5'-monophosphate. Eur J Biochem. 1981 Mar 16;115(1):17–22. doi: 10.1111/j.1432-1033.1981.tb06191.x. [DOI] [PubMed] [Google Scholar]
  19. Wong E. H., Ooi S. O., Wong E. H., Ooi S. O., Loten E. G., Sneyd J. G. The action of adenosine in relation to that of insulin on the low-Km cyclic AMP phosphodiesterase in rat adipocytes. Biochem J. 1985 May 1;227(3):815–821. doi: 10.1042/bj2270815. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Wong E. H., Smith J. A., Jarett L. Effect of adenosine on insulin activation of rat adipocyte pyruvate dehydrogenase. FEBS Lett. 1984 Sep 17;175(1):68–71. doi: 10.1016/0014-5793(84)80571-2. [DOI] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES