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. 1985 Nov 15;232(1):305–308. doi: 10.1042/bj2320305

Mechanisms of thrombin-induced modifications of human platelet cytoskeleton.

F Sinigaglia, C L Balduini, A Bisio, C Balduini
PMCID: PMC1152877  PMID: 4084237

Abstract

Thrombin treated with phenylmethanesulphonyl fluoride, like active enzyme, promotes modifications to human platelet cytoskeleton. The removal of active thrombin by hirudin partially reverses this process. Chymotrypsin-treated platelets do not modify their cytoskeleton after thrombin stimulus, but are still able to increase their adhesiveness to collagen. It is concluded that thrombin influences the cytoskeleton and adhesion by non-enzymic mechanisms which may be mediated by different modulators.

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Selected References

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