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. 1986 Jan 1;233(1):287–289. doi: 10.1042/bj2330287

Enhancement of glucagon secretion from isolated rat islets of Langerhans by phorbol 12-myristate 13-acetate.

C S Hii, J Stutchfield, S L Howell
PMCID: PMC1153019  PMID: 3513761

Abstract

The phorbol ester 4 beta-phorbol 12-myristate 13-acetate (PMA), at concentrations of 0.1 microM and above, stimulated secretion of glucagon and of insulin from isolated rat islets of Langerhans incubated in the presence of 5.5 mM-glucose. Stimulation of secretion of both hormones by 1 microM-PMA persisted in the absence of external Ca2+, and could be abolished by incubating the islets at 4 degrees C. These findings suggest a role of protein kinase C in the alpha-cell (and beta-cell) secretory mechanism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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