Skip to main content
NCBI home page
Biochemical Journal logoLink to Biochemical Journal
. 1984 Feb 1;217(3):859–862. doi: 10.1042/bj2170859

Metallothionein-I in the plasma and liver of neonatal rats.

R K Mehra, I Bremner
PMCID: PMC1153293  PMID: 6712602

Abstract

The concentrations of metallothionein-I in the plasma and liver of neonatal rats were measured by radioimmunoassay. Plasma concentrations of the protein in male and female 4-day-old rats were 350 and 740 ng/ml respectively, and declined rapidly to only 3.5 ng/ml at 32 days of age. Concentrations in liver were also high in the newborn rats (200 micrograms/g), and declined from 12 days of age onwards.

Full text

PDF
859

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersen R. D., Winter W. P., Maher J. J., Bernstein I. A. Turnover of metallothioneins in rat liver. Biochem J. 1978 Jul 15;174(1):327–338. doi: 10.1042/bj1740327. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bremner I., Davies N. T. The induction of metallothionein in rat liver by zinc injection and restriction of food intake. Biochem J. 1975 Sep;149(3):733–738. doi: 10.1042/bj1490733. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bremner I. Factors influencing the occurrence of copper-thioneins in tissues. Experientia Suppl. 1979;34:273–280. doi: 10.1007/978-3-0348-6493-0_20. [DOI] [PubMed] [Google Scholar]
  4. Bremner I., Williams R. B., Young B. W. Distribution of copper and zinc in the liver of the developing sheep foetus. Br J Nutr. 1977 Jul;38(1):87–92. doi: 10.1079/bjn19770064. [DOI] [PubMed] [Google Scholar]
  5. Chang C. C., Vander Mallie R. J., Garvey J. S. A radioimmunoassay for human metallothionein. Toxicol Appl Pharmacol. 1980 Aug;55(1):94–102. doi: 10.1016/0041-008x(80)90224-0. [DOI] [PubMed] [Google Scholar]
  6. Garvey J. S., Chang C. C. Detection of circulating metallothionein in rats injected with zinc or cadmium. Science. 1981 Nov 13;214(4522):805–807. doi: 10.1126/science.7292012. [DOI] [PubMed] [Google Scholar]
  7. Little J. M., Richey J. E., Van Thiel D. H., Lester R. Taurocholate pool size and distribution in the fetal rat. J Clin Invest. 1979 May;63(5):1042–1049. doi: 10.1172/JCI109373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Mason R., Bakka A., Samarawickrama G. P., Webb M. Metabolism of zinc and copper in the neonate: accumulation and function of (Zn, Cu)-metallothionein in the liver of the newborn rat. Br J Nutr. 1981 Mar;45(2):375–389. doi: 10.1079/bjn19810113. [DOI] [PubMed] [Google Scholar]
  9. Mehra R. K., Bremner I. Development of a radioimmunoassay for rat liver metallothionein-I and its application to the analysis of rat plasma and kidneys. Biochem J. 1983 Aug 1;213(2):459–465. doi: 10.1042/bj2130459. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Nordberg G. F., Garvey J. S., Chang C. C. Metallothionein in plasma and urine of cadmium workers. Environ Res. 1982 Jun;28(1):179–182. doi: 10.1016/0013-9351(82)90167-0. [DOI] [PubMed] [Google Scholar]
  11. Panemangalore M., Banerjee D., Onosaka S., Cherian M. G. Changes in the intracellular accumulation and distribution of metallothionein in rat liver and kidney during postnatal development. Dev Biol. 1983 May;97(1):95–102. doi: 10.1016/0012-1606(83)90067-2. [DOI] [PubMed] [Google Scholar]
  12. Shaikh Z. A., Hirayama K. Metallothionein in the extracellular fluids as an index of cadmium toxicity. Environ Health Perspect. 1979 Feb;28:267–271. doi: 10.1289/ehp.7928267. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES