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. 1984 Mar 1;218(2):371–377. doi: 10.1042/bj2180371

Effect of thioacetamide on cytochrome P-450 synthesis in rat liver.

S Satyabhama, G Padmanaban
PMCID: PMC1153350  PMID: 6712620

Abstract

A single injection of thioacetamide to rats results in a striking decrease in liver cytochrome P-450. The drug blocks the phenobarbitone-mediated induction of cytochrome P-450b. Under these conditions, there is a decrease in the synthesis of cytochrome P-450b, which is essentially due to a decrease in the amount of translatable mRNA for cytochrome P-450b. This effect of thioacetamide is not due to a general effect on protein synthesis or polyribosome stability. Multiple injections of thioacetamide also decrease the synthesis of cytochrome P-450b and the amounts of its translatable mRNA.

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Selected References

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