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. 2002 Aug;22(4):455–462. doi: 10.1023/A:1021067822435

Transient Forebrain Ischemia Increases the Blood-Brain Barrier Permeability for Albumin in Stroke-Prone Spontaneously Hypertensive Rats

Csongor S Ábrahám 1, Noboru Harada 1, Mária A Deli 1, Masami Niwa 1
PMCID: PMC11533779  PMID: 12507394

Abstract

1. The aim of the present study was to reveal the effect of transient forebrain ischemia on the regional and temporal changes in the permeability of the blood-brain barrier (BBB) permeability for sodium fluorescein (MW: 376 Da) and Evan's blue-labeled albumin (MW: 67 kDa) in stroke-prone spontaneously hypertensive rats (SHRSP).

2. BBB permeability was significantly higher in the brain regions of 16-week-old control SHRSP than those in age-matched normotensive Wistar-Kyoto rats.

3. Transient forebrain ischemia evoked by 10-min bilateral carotid occlusion increased the permeability of the BBB for albumin, but not for sodium fluorescein, after 6 and 24 h of reperfusion in brain regions of SHRSP.

4. Extravasation of serum macromolecules may contribute to neuronal loss and development of hypertensive encephalopathy in SHRSP.

Keywords: blood-brain barrier permeability, cerebral ischemia-reperfusion, Evan's blue-albumin, sodium fluorescein, stroke-prone spontaneously hypertensive rat

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