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. 1984 Mar 1;218(2):625–628. doi: 10.1042/bj2180625

Specificity studies on the oligosaccharide neuraminidase of human fibroblasts.

K Mendla, M Cantz
PMCID: PMC1153381  PMID: 6424662

Abstract

Competition and thermal inactivation experiments with different potential natural substrates indicated that in homogenates of human fibroblasts one single enzyme is acting on both (alpha 2-3) and (alpha 2-6) sialosyl linkages of oligosaccharides and glycoproteins, but not of the ganglioside GM3. N-Acetylneuraminic and 2-deoxy-2,3-dehydro-N-acetylneuraminic acids are competitive inhibitors, whereas chondroitin 4-sulphate and the drug Suramin are potent inhibitors of undefined type.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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