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. 1984 Mar 1;218(2):629–632. doi: 10.1042/bj2180629

Calmodulin antagonists decrease the binding of epidermal growth factor to transformed, but not to normal, human fibroblasts.

P V Bodine, J T Tupper
PMCID: PMC1153382  PMID: 6324761

Abstract

Four psychoactive agents which inhibit calmodulin activity were used to study their effect on the binding of epidermal growth factor (EGF) to normal and simian-virus-40-transformed human fibroblasts (WI38). These calmodulin antagonists decreased the binding of 125I-labelled EGF to the transformed, but not to the normal, cell in a dose-dependent manner. The mechanism of this effect appears to be due to a decrease in the apparent affinity of the plasma-membrane EGF receptor for the EGF molecule.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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